Binge Alcohol Consumption Elevates Sympathetic Transduction to Blood Pressure: A Randomized Controlled Trial.

IF 6.9 1区医学 Q1 PERIPHERAL VASCULAR DISEASE Hypertension Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI:10.1161/HYPERTENSIONAHA.124.23416

Jeremy A Bigalke, Ian M Greenlund, Tatiana X Solis-Montenegro, John J Durocher, Michael J Joyner, Jason R Carter

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Abstract

Background: Alcohol consumption is associated with cardiovascular disease, and the sympathetic nervous system is a suspected mediator. The present study investigated sympathetic transduction of muscle sympathetic nerve activity to blood pressure at rest and in response to cold pressor test following evening binge alcohol or fluid control, with the hypothesis that sympathetic transduction would be elevated the morning after binge alcohol consumption.

Methods: Using a randomized, fluid-controlled (FC) crossover design, 26 healthy adults (12 male, 14 female, 25±6 years, 27±4 kg/m²) received an evening binge alcohol dose and a FC. All participants underwent next-morning autonomic-cardiovascular testing consisting of muscle sympathetic nerve activity, beat-to-beat blood pressure, and heart rate during a 10-minute rest period and a 2-minute cold pressor test. Sympathetic transduction was assessed at rest and during the cold pressor test in both experimental conditions.

Results: Evening alcohol increased heart rate (FC: 60±9 versus alcohol: 64±9 bpm; P=0.010) but did not alter resting mean arterial pressure (FC: 80±6 versus alcohol: 80±7 mm Hg; P=0.857) or muscle sympathetic nerve activity (FC: 18±9 versus alcohol: 20±8 bursts/min; P=0.283). Sympathetic transduction to mean arterial pressure (time×condition; P=0.003), diastolic blood pressure (time×condition; P=0.010), and total vascular conductance (time×condition; P=0.004) was augmented after alcohol at rest. Sympathetic transduction during the cold pressor test was also elevated after evening binge alcohol consumption (P=0.002).

Conclusions: These findings suggest that evening binge alcohol consumption leads to augmented morning-after sympathetic transduction of muscle sympathetic nerve activity to blood pressure, highlighting a new mechanism whereby chronic or excessive alcohol consumption contributes to cardiovascular disease progression via altered end-organ responsiveness to sympathetic neural outflow.

Registration: URL: https://clinicaltrials.gov/study/NCT03567434; Unique identifier: NCT03567434.

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酗酒会提高交感神经对血压的传导：随机对照试验

背景：饮酒与心血管疾病有关，而交感神经系统被怀疑是一种介导因素。本研究调查了肌肉交感神经活动对静息状态下血压以及晚上酗酒或液体控制后冷压试验反应的交感传导，假设交感传导会在酗酒后的早晨升高：采用随机、体液控制（FC）交叉设计，26 名健康成人（12 名男性，14 名女性，25±6 岁，27±4 kg/m2）接受了晚间暴饮暴食酒精剂量和 FC。所有参与者都在第二天早上接受了自律神经-心血管测试，包括肌肉交感神经活动、逐搏血压、10 分钟休息期间的心率以及 2 分钟冷加压测试。在两种实验条件下，交感神经传导均在休息时和冷压测试期间进行评估：结果：晚间酒精会增加心率（FC：60±9 与酒精：64±9 bpm；P=0.010），但不会改变静息平均动脉压（FC：80±6 与酒精：80±7 mm Hg；P=0.857）或肌肉交感神经活动（FC：18±9 与酒精：20±8 次/分钟；P=0.283）。休息时饮酒后，交感神经对平均动脉压（时间×条件；P=0.003）、舒张压（时间×条件；P=0.010）和总血管传导（时间×条件；P=0.004）的传导增强。晚间酗酒后，冷压试验中的交感神经传导也会升高（P=0.002）：这些研究结果表明，傍晚酗酒会导致清晨肌肉交感神经活动对血压的交感转导增强，突出了一种新的机制，即长期或过量饮酒会通过改变内脏器官对交感神经外流的反应，导致心血管疾病的发展：URL: https://www.clinicaltrials.gov; Unique identifier：NCT03567434。

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来源期刊

Hypertension 医学-外周血管病

CiteScore

15.90

自引率

4.80%

发文量

1006

审稿时长

1 months

期刊介绍： Hypertension presents top-tier articles on high blood pressure in each monthly release. These articles delve into basic science, clinical treatment, and prevention of hypertension and associated cardiovascular, metabolic, and renal conditions. Renowned for their lasting significance, these papers contribute to advancing our understanding and management of hypertension-related issues.