B Cells Infiltration Potentially Responded Better to Systemic Corticoids in Oral Lichen Planus and Oral Lichenoid Lesions.

IF 4.5 2区 医学 Q2 CELL BIOLOGY Inflammation Pub Date : 2024-08-09 DOI:10.1007/s10753-024-02112-4
Ming-Hua Feng, Yi-Rao Lai, Yi-Wen Deng, Xi-Ye Li, Lei Pan, Zhen Tian, Guo-Yao Tang, Yu-Feng Wang
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Abstract

Oral lichen planus (OLP) and oral lichenoid lesion (OLL) are chronic inflammatory diseases involving the oral mucosa. B cells infiltration in OLP and OLL, however, little is known about these cells in OLP and OLL. To analyze the function and infiltrating features of B lymphocytes in OLP and OLL, and to preliminarily evaluate their correlation with clinical outcomes. Tissue samples were collected from OLP, OLL, and healthy mucosa. The phenotypes and amounts of B cells in tissues were analyzed by single-cell sequencing. Their proportion and infiltrating features in tissues were examined by immunohistochemistry and immunofluorescence. With the systemic medication of corticoids, the correlation between B cells infiltrating characteristics and the clinical outcomes were evaluated. A quantified proportion increase of B cells was shown in both OLP and OLL. B cells in OLP demonstrated heightened activation and enhanced regulation in immune response. A cohort of 100 patients with OLP/OLL and 13 healthy controls were examined to investigate the B cells infiltration pattern. B cells were distributed in the superficial layer of lamina propria in 92.9% and 41.9% of OLP and OLL, respectively(P < 0.01); focally distributed in 25.0% and 62.9% of OLP and OLL, respectively(P < 0.01). With the systemic medication of corticoids, the cases with B cell infiltration (B+) in OLP and OLL groups showed a statistically significant reduction in REU scores before and after treatment (P < 0.01). B cells are widely present in OLP and OLL, and B cell infiltration in OLP and OLL are related to the better therapeutic effect of oral corticoids.

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在口腔扁平苔藓和口腔苔癣病变中,B 细胞浸润可能对全身性可的松类药物有更好的反应。
口腔扁平苔藓(OLP)和口腔苔癣(OLL)是涉及口腔黏膜的慢性炎症性疾病。B 淋巴细胞在 OLP 和 OLL 中有浸润作用,但人们对这些细胞在 OLP 和 OLL 中的情况知之甚少。为了分析 B 淋巴细胞在 OLP 和 OLL 中的功能和浸润特征,并初步评估它们与临床结果的相关性。从 OLP、OLL 和健康粘膜中采集组织样本。通过单细胞测序分析了组织中B细胞的表型和数量。通过免疫组化和免疫荧光检查了它们在组织中的比例和浸润特征。在全身使用皮质激素的情况下,评估了 B 细胞浸润特征与临床结果之间的相关性。OLP和OLL中的B细胞都出现了量化的比例增长。OLP 中的 B 细胞在免疫反应中表现出更高的活化和更强的调节能力。研究人员对100名OLP/OLL患者和13名健康对照者进行了研究,以调查B细胞的浸润模式。分别有 92.9% 和 41.9% 的 OLP 和 OLL 患者的 B 细胞分布在固有膜浅层(P +),OLP 组和 OLL 组的 REU 评分在治疗前后均有统计学意义的显著降低(P +)。
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来源期刊
Inflammation
Inflammation 医学-免疫学
CiteScore
9.70
自引率
0.00%
发文量
168
审稿时长
3.0 months
期刊介绍: Inflammation publishes the latest international advances in experimental and clinical research on the physiology, biochemistry, cell biology, and pharmacology of inflammation. Contributions include full-length scientific reports, short definitive articles, and papers from meetings and symposia proceedings. The journal''s coverage includes acute and chronic inflammation; mediators of inflammation; mechanisms of tissue injury and cytotoxicity; pharmacology of inflammation; and clinical studies of inflammation and its modification.
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