Bilateral cochlear fibrosis complicating chronic myeloid leukemia: A CARE case report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-07 DOI:10.1016/j.anorl.2024.07.003

G Lahlou, H Daoudi, C Djian, I Mosnier

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Abstract

Purpose: We report the second case of bilateral sudden sensorineural hearing loss with intracochlear fibrosis due to chronic myeloid leukemia.

Case report: A 44-year-old man presented to the emergency department with rapidly progressive bilateral hearing loss, tinnitus and vertigo, associated with dyspnea. Chronic myeloid leukemia complicated by pulmonary and cochleovestibular leukostasis was diagnosed, and cytoreductive treatment was started. Despite this treatment, bilateral total hearing loss and complete vestibular deficit persisted. MRI showed bilateral labyrinthitis, and emergency cochlear implantation was indicated. During surgery, inflammatory intracochlear tissue made electrode array insertion possible only against resistance. One year after implantation, there was significant improvement in speech recognition and communication scores.

Conclusion: In case of sudden sensorineural hearing loss induced by chronic myeloid leukemia, treatment should be as fast as possible, with prompt cochlear implantation in case of definitive profound hearing loss, because of the risk of cochlear fibrosis and ossification.

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慢性髓性白血病并发双侧耳蜗纤维化：CARE病例报告

目的：我们报告了第二例慢性髓性白血病导致的双侧突发性感音神经性听力损失并伴有耳蜗内纤维化的病例：一名 44 岁男子因双侧听力急剧下降、耳鸣和眩晕并伴有呼吸困难到急诊科就诊。确诊为慢性髓性白血病，并发肺和耳蜗白血病，并开始进行细胞再生治疗。尽管进行了治疗，但双侧听力完全丧失和前庭完全缺损的情况依然存在。磁共振成像显示患者患有双侧耳迷路炎，因此需要紧急植入人工耳蜗。手术过程中，由于耳蜗内组织发炎，电极阵列的插入受到阻力。植入手术一年后，患者的语言识别能力和交流能力显著提高：结论：对于慢性粒细胞白血病诱发的突发性感音神经性听力损失，由于存在耳蜗纤维化和骨化的风险，应尽快进行治疗，并在出现明确的深度听力损失时及时植入人工耳蜗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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