Cervical cancer screening efficacy using SurePath, ThinPrep and conventional cytology: A large data set analysis from the Japan Cancer Society

IF 1.2 4区医学 Q4 CELL BIOLOGY Cytopathology Pub Date : 2024-08-08 DOI:10.1111/cyt.13431

Takahiro Koyanagi, Hiroyuki Fujiwara, Kouji Yamamoto, Mitsuaki Suzuki, Tadao Kakizoe

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Abstract

Objective

Over the past decade, liquid-based cytology has replaced conventional cytology for cervical cancer screening in many countries, including Japan. We aimed to evaluate the efficacy of liquid-based cytology using a large database and compare two major liquid-based cytology platforms, SurePath and ThinPrep, to conventional cytology.

Methods

Cervical cancer screening data were collected from the Japan Cancer Society between 2015 and 2019. The efficacy of liquid-based and conventional cytology in detecting cervical intraepithelial neoplasia (CIN) was evaluated. Detection rates and positive predictive values were compared using a Poisson regression model.

Results

We collected data of 3,918,149 participants, including 2,248,202 conventional cytology, 874,807 SurePath and 795,140 ThinPrep smears. The detection rate of CIN2 or more was 1.14 times higher using SurePath than that using conventional cytology (95% confidence interval [CI], 1.09–1.20; p < 0.001). Contrastingly, the detection rate of CIN2 or more was 0.91 times lower using ThinPrep (95% CI, 0.86–0.96; p < 0.001). The detection rates of CIN3 or more did not differ significantly between SurePath and conventional cytology (detection rate ratio, 1.04; 95% CI, 0.97–1.12; p = 0.224). The positive predictive value ratios of CIN2 or more were 0.80 using SurePath (95% CI, 0.76–0.84; p < 0.001) and 0.83 using ThinPrep (95% CI, 0.79–0.87; p < 0.001) compared with conventional cytology.

Conclusions

Liquid-based cytology, particularly SurePath, was useful for detecting CIN2 or higher in population-based cervical cancer screening. Further widespread use of liquid-based cytology methods would lead to efficient detection of cervical precancerous lesions.

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使用 SurePath、ThinPrep 和传统细胞学方法进行宫颈癌筛查的效果：来自日本癌症协会的大型数据集分析。

目的：过去十年间，在包括日本在内的许多国家，液基细胞学已取代传统细胞学用于宫颈癌筛查。我们旨在利用大型数据库评估液基细胞学的疗效，并将 SurePath 和 ThinPrep 这两大液基细胞学平台与传统细胞学进行比较：方法：从日本癌症协会收集了2015年至2019年期间的宫颈癌筛查数据。评估了液基细胞学和传统细胞学在检测宫颈上皮内瘤变（CIN）方面的功效。使用泊松回归模型对检测率和阳性预测值进行了比较：我们收集了 3,918,149 名参与者的数据，其中包括 2,248,202 份常规细胞学涂片、874,807 份 SurePath 涂片和 795,140 份 ThinPrep 涂片。使用 SurePath 的 CIN2 或以上的检出率是使用传统细胞学方法的 1.14 倍（95% 置信区间 [CI]，1.09-1.20；P 结论：使用 SurePath 的 CIN2 或以上的检出率是使用传统细胞学方法的 1.14 倍：液基细胞学，尤其是 SurePath，有助于在人群宫颈癌筛查中检测出 CIN2 或更高的宫颈癌。进一步广泛使用液基细胞学方法将有助于有效检测宫颈癌前病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.