The mechanism of lovastatin in suppressing the proliferation of esophageal squamous cell carcinoma based on proteomics

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-08-08 DOI:10.1002/jgm.3722

Feng Peng, Lili Zhu, Jiang Fan, Fu Yang

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Abstract

Background

Lovastatin, a type of statin usually considered as a lipid-lowering drug that lowers blood cholesterol and low-density lipoprotein cholesterol levels, has been rediscovered to have anticancer activity. Fewer studies exist regarding the effect of lovastatin on esophageal squamous cell carcinoma (ESCC).

Methods

Here, we report that lovastatin shows anticancer effect on ESCC By affecting the mitochondrial autophagy pathway. Moreover, based on proteomics and computer molecular simulations found that RAB38 and RAB27A may be a target of lovastatin.

Results

We observed that autophagy of mitochondria is inhibited by lovastatin, affecting esophageal squamous cell proliferation. There is a possible link between the expression of RAB38, RAB27A and immune cell invasion in esophageal cancer.

Conclusions

These results demonstrate the huge potential of lovastatin as an RAB38, RAB27A inhibitor in esophageal cancer chemotherapy and chemoprevention.

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基于蛋白质组学研究洛伐他汀抑制食管鳞癌增殖的机制

背景：洛伐他汀是一种他汀类药物，通常被认为是一种降脂药物，可降低血液中胆固醇和低密度脂蛋白胆固醇的水平。方法：在此，我们报告了洛伐他汀通过影响线粒体自噬途径对食管鳞状细胞癌（ESCC）的抗癌作用。此外，基于蛋白质组学和计算机分子模拟发现，RAB38和RAB27A可能是洛伐他汀的靶点：结果：我们观察到洛伐他汀抑制了线粒体的自噬，从而影响了食管鳞状细胞的增殖。RAB38、RAB27A的表达与食管癌免疫细胞侵袭之间可能存在联系：这些结果表明，洛伐他汀作为一种 RAB38、RAB27A 抑制剂，在食管癌化疗和化学预防方面具有巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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