Differential contributions of performance-based and parental reports of executive functioning on memory in pediatric focal and generalized epilepsies

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Epilepsy Research Pub Date : 2024-08-08 DOI:10.1016/j.eplepsyres.2024.107423

Bruna M. Schneider , Erica M. Krapf , Kathleen E. Hassara , Lisa D. Stanford , Dalin T. Pulsipher

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Abstract

Children with epilepsy often experience deficits in both executive functioning (EF) and memory. However, how these two domains interact and relate to specific epilepsy types remains unclear. This study compared two groups of children: those with localization-related epilepsy (LRE) and those with genetic generalized epilepsy (GGE). We aimed to understand how performance-based and parent-reported EF differentially contribute to understanding memory function in each group.

We examined neuropsychological measures assessing memory and EF in 75 children with LRE and 91 with GGE. Multiple linear regressions explored the impact of EF on memory performance.

Performance-based EF scores accounted for greater variance in memory scores than parental EF reports. However, performance-based EF measures explained much more variance in visual memory for LRE than GGE and explained much more variance in verbal memory for the GGE group. Parental reports of EF contributed marginally to understanding variance.

These findings suggest differential relationships between EF and memory based on epilepsy type. Performance-based EF measures appear more reliable at understanding memory variance than did parent reports. Our results have potential clinical implications for tailoring neuropsychological assessment and intervention for children with different epilepsy types.

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小儿局灶性癫痫和全身性癫痫患者的执行功能表现报告和家长报告对记忆力的不同贡献。

患有癫痫的儿童往往在执行功能（EF）和记忆力方面都存在缺陷。然而，这两个领域如何相互作用以及与特定癫痫类型的关系仍不清楚。本研究比较了两组儿童：局部相关性癫痫（LRE）患儿和遗传性广泛性癫痫（GGE）患儿。我们旨在了解基于表现的 EF 和家长报告的 EF 如何对理解每组儿童的记忆功能起到不同的作用。我们对 75 名 LRE 儿童和 91 名 GGE 儿童进行了神经心理学测量，以评估他们的记忆力和 EF。多重线性回归探讨了EF对记忆表现的影响。与父母的 EF 报告相比，以表现为基础的 EF 分数能解释更大的记忆分数差异。然而，以成绩为基础的 EF 测量对 LRE 视觉记忆差异的解释远大于对 GGE 的解释，对 GGE 组言语记忆差异的解释也远大于对 LRE 组的解释。父母的 EF 报告对理解差异的贡献微乎其微。这些研究结果表明，根据癫痫类型，EF 与记忆之间存在不同的关系。与父母的报告相比，基于表现的EF测量在理解记忆差异方面似乎更可靠。我们的研究结果对于为不同癫痫类型的儿童量身定制神经心理评估和干预具有潜在的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.