Ulcerative colitis: the healing power of macrophages.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Tissue Barriers Pub Date : 2024-08-10 DOI:10.1080/21688370.2024.2390218

Nesa Kazemifard, Nafiseh Golestani, Kasra Jahankhani, Maryam Farmani, Shaghayegh Baradaran Ghavami

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Abstract

Ulcerative colitis (UC) is a chronic and debilitating disorder that falls under the broad category of inflammatory bowel disease (IBD). Therefore, affects the colon and rectum, resulting in inflammation and ulcers in the lining of these organs. Over the years, there has been a significant shift in the management of UC. The focus has moved from achieving symptom-free daily living to attaining mucosal healing. Mucosal healing means completely restoring the colon and rectum's lining, significantly reducing the risk of complications and relapse. Macrophages are a crucial component of the immune system that play a vital role in the regeneration and repair of colonic ulcers. These immune cells are responsible for production of a variety of cytokines and growth factors that facilitate tissue repair. Macrophages are responsible for maintaining a balance between inflammation and healing. When this balance is disrupted, it can lead to chronic inflammation and tissue damage, exacerbating UC symptoms. Thus, this review aims to investigate the contribution of macrophages to mucosal repair and remission maintenance in UC patients.

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溃疡性结肠炎：巨噬细胞的治愈能力

溃疡性结肠炎（UC）是一种使人衰弱的慢性疾病，属于广义的炎症性肠病（IBD）范畴。溃疡性结肠炎会影响结肠和直肠，导致这些器官的内膜发炎和溃疡。多年来，UC 的治疗方法发生了重大转变。重点已从实现无症状的日常生活转向实现粘膜愈合。粘膜愈合意味着完全恢复结肠和直肠的内膜，大大降低并发症和复发的风险。巨噬细胞是免疫系统的重要组成部分，在结肠溃疡的再生和修复中发挥着至关重要的作用。这些免疫细胞负责产生各种细胞因子和生长因子，促进组织修复。巨噬细胞负责维持炎症和愈合之间的平衡。一旦这种平衡被打破，就会导致慢性炎症和组织损伤，从而加重 UC 症状。因此，本综述旨在研究巨噬细胞对 UC 患者粘膜修复和缓解维持的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.