Crosstalk between circular RNAs and the STAT3 signaling pathway in human cancer

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2024-08-08 DOI:10.1016/j.bbagrm.2024.195051

Mansour Almouh , Chadi Soukkarieh , Morshed Kassouha , Samer Ibrahim

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Abstract

Circular RNAs (circRNAs) are endogenous covalently closed single-stranded RNAs produced by reverse splicing of pre-mRNA. Emerging evidence suggests that circRNAs contribute to cancer progression by modulating the oncogenic STAT3 signaling pathway, which plays key roles in human malignancies. STAT3 signaling-related circRNAs expression appears to be extensively dysregulated in diverse cancer types, where they function either as tumor suppressors or oncogenes. However, the biological effects of STAT3 signaling-related circRNAs and their associations with cancer have not been systematically studied before. Given this, shedding light on the interaction between circRNAs and STAT3 signaling pathway in human malignancies may provide several novel insights into cancer therapy. In this review, we provide a comprehensive introduction to the molecular mechanisms by which circRNAs regulate STAT3 signaling in cancer progression, and the crosstalk between STAT3 signaling-related circRNAs and other signaling pathways. We also further discuss the role of the circRNA/STAT3 axis in cancer chemotherapy sensitivity.

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人类癌症中环状 RNA 与 STAT3 信号通路之间的相互影响

环状 RNA（circRNA）是由前 mRNA 反向剪接产生的内源性共价封闭单链 RNA。新的证据表明，环状 RNA 通过调节在人类恶性肿瘤中起关键作用的致癌 STAT3 信号通路，促进癌症的发展。在各种癌症类型中，STAT3 信号相关的 circRNAs 表达似乎广泛失调，它们要么作为肿瘤抑制因子发挥作用，要么作为致癌基因发挥作用。然而，关于 STAT3 信号相关 circRNAs 的生物效应及其与癌症的关系，以前还没有系统的研究。有鉴于此，揭示人类恶性肿瘤中 circRNA 与 STAT3 信号通路之间的相互作用可能会为癌症治疗提供一些新的见解。在这篇综述中，我们将全面介绍 circRNA 在癌症进展过程中调控 STAT3 信号转导的分子机制，以及 STAT3 信号转导相关的 circRNA 与其他信号转导通路之间的相互影响。我们还进一步讨论了 circRNA/STAT3 轴在癌症化疗敏感性中的作用。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.