Raghad Alhajaji, Mayada Mohammad Samkari, Mona A Althobaiti, Bashaer Ruddah Al-Ahmadi, Alaa Mohammed Bugis, Amjad Mohammed Bugis, Fatimah Yaseen Sabbagh, Somaya A Althobaiti, Amro S Bukari, Safenaz Meshal Alqurashi, Hana Abdullah Mshrai, Omar Ahmed Abdelwahab
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引用次数: 0
Abstract
Background: Spontaneous bacterial peritonitis (SBP) represents a critical and potentially lethal condition that typically develops in individuals with liver cirrhosis. This meta-analysis aimed to assess diabetes mellitus (DM) as a risk factor for SBP in liver cirrhotic patients.
Methods: Following PRISMA guidelines, fifteen studies were included, for a total of 76 815 patients. The risk of bias was assessed using the Newcastle-Ottawa scale (NOS). We represented the results as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Additionally, we pooled the hazard ratios (HR) for developing SBP in patients with DM from the included studies.
Results: The meta-analysis shows a significantly increased risk of SBP in cirrhotic patients with DM (HR: 1.26; 95% CI [1.05-1.51], P=.01; HR: 1.70; 95% CI [1.32-2.18], P<.001).
Conclusions: The study signifies that DM is an independent risk factor for SBP, emphasizing the need for targeted preventive measures in this specific population.
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