Efficacy and safety of autologous platelet-rich plasma in anal fistula: a systematic review and meta-analysis.

Annals of Saudi medicine Pub Date : 2024-07-01 Epub Date: 2024-08-01 DOI:10.5144/0256-4947.2024.264

Yuanhui Xu, Lin Ma, Keliang Jia, Xiaoling Wu, Chang Ge

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Abstract

Introduction: This study aimed to determine the efficacy and safety of autologous PRP in anal fistula.

Methods: The search was done in electronic databases such as; PubMed, Scopus, Google Scholar, Embase, and Cochrane Library. The outcomes investigated in this study were the rate of improvement, the rate of recurrence, and the rate of fecal incontinence.

Results: Cure, incontinence, and recurrence rates were 68% (95% CI, .60-.76), 27% (95% CI, .12-.46), and 18% (95% CI, .12-.26), respectively. The pooled improvement ratio in patients treated with PRP compared to control group was 1.35 times, which was statistically significant (pooled OR=1.35, 95% CI, 1.14-1.60, P<001). The pooled recurrence ratio in patients treated with PRP compared to control group was 1.17, which was not statistically significant (pooled OR=1.17, 95% CI, 0.44-3.11).

Discussion: Platelet-rich plasma is an effective method of healing people with anal fistula.

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自体富血小板血浆治疗肛瘘的有效性和安全性：系统回顾和荟萃分析。

简介：本研究旨在确定自体PRP治疗肛瘘的有效性和安全性：本研究旨在确定自体 PRP 治疗肛瘘的有效性和安全性：在 PubMed、Scopus、Google Scholar、Embase 和 Cochrane Library 等电子数据库中进行了搜索。本研究调查的结果为痊愈率、复发率和大便失禁率：治愈率、大便失禁率和复发率分别为 68% (95% CI, .60-.76)、27% (95% CI, .12-.46) 和 18% (95% CI, .12-.26)。与对照组相比，使用富血小板血浆治疗的患者的总改善率为 1.35 倍，具有统计学意义（总 OR=1.35，95% CI，1.14-1.60，PDiscussion：富血小板血浆是治愈肛瘘患者的有效方法。

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Annals of Saudi medicine

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