Cristina Quílez , Luís B. Bebiano , Eleri Jones , Uroš Maver , Luca Meesters , Piotr Parzymies , Emma Petiot , Gijs Rikken , Ignacio Risueño , Hamza Zaidi , Tanja Zidarič , Sander Bekeschus , Ellen H. van den Bogaard , Matthew Caley , Helen Colley , Nuria Gago López , Sophia Letsiou , Christophe Marquette , Tina Maver , Rúben F. Pereira , Diego Velasco
{"title":"Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments","authors":"Cristina Quílez , Luís B. Bebiano , Eleri Jones , Uroš Maver , Luca Meesters , Piotr Parzymies , Emma Petiot , Gijs Rikken , Ignacio Risueño , Hamza Zaidi , Tanja Zidarič , Sander Bekeschus , Ellen H. van den Bogaard , Matthew Caley , Helen Colley , Nuria Gago López , Sophia Letsiou , Christophe Marquette , Tina Maver , Rúben F. Pereira , Diego Velasco","doi":"10.1016/j.jid.2024.04.032","DOIUrl":null,"url":null,"abstract":"<div><div>Skin in vitro models offer much promise for research, testing drugs, cosmetics, and medical devices, reducing animal testing and extensive clinical trials. There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have been approved for preclinical studies in cosmetics, pharmaceuticals, and chemicals. However, development of physiologically reliable in vitro human skin models remains in its infancy. This review reports on advances in in vitro complex skin models to study skin homeostasis, aging, and skin disease.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 12","pages":"Pages 2650-2670"},"PeriodicalIF":5.7000,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative Dermatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022202X24014994","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Skin in vitro models offer much promise for research, testing drugs, cosmetics, and medical devices, reducing animal testing and extensive clinical trials. There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have been approved for preclinical studies in cosmetics, pharmaceuticals, and chemicals. However, development of physiologically reliable in vitro human skin models remains in its infancy. This review reports on advances in in vitro complex skin models to study skin homeostasis, aging, and skin disease.
期刊介绍：
Journal of Investigative Dermatology (JID) publishes reports describing original research on all aspects of cutaneous biology and skin disease. Topics include biochemistry, biophysics, carcinogenesis, cell regulation, clinical research, development, embryology, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, percutaneous absorption, pharmacology, photobiology, physiology, skin structure, and wound healing
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