Jie Li , Hao Chang , Pengzhe Zhang , Liyu Hou , Wei Li , Yixin Zhang , Zhiqi Lao
{"title":"A novel tumor theranostic strategy based on metabolic glycoengineering and disulfidptosis†‡","authors":"Jie Li , Hao Chang , Pengzhe Zhang , Liyu Hou , Wei Li , Yixin Zhang , Zhiqi Lao","doi":"10.1039/d4ob01027b","DOIUrl":null,"url":null,"abstract":"<div><p>Traditional metabolic glycoengineering involves participation of a monofunctional unnatural monosaccharide. To broaden the application boundary of this powerful technique, a bifunctional molecule, Ac<sub>4</sub>ManNSSN<sub>3</sub>, is designed and applied for a tumor theranostic strategy in this work. The results from both cell and animal experiments show good <em>in situ</em> tumor detection and tumor inhibition effects.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024006955","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Traditional metabolic glycoengineering involves participation of a monofunctional unnatural monosaccharide. To broaden the application boundary of this powerful technique, a bifunctional molecule, Ac4ManNSSN3, is designed and applied for a tumor theranostic strategy in this work. The results from both cell and animal experiments show good in situ tumor detection and tumor inhibition effects.
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