Sodium fluorescein-guided resection of brain metastases: A needed approach or an option? A systematic review and meta-analysis.

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY Acta Neurochirurgica Pub Date : 2024-08-12 DOI:10.1007/s00701-024-06223-7

Mohammad Amin Dabbagh Ohadi, Mohammad Dashtkoohi, Mohammad Reza Babaei, Raha Zamani, Mohadese Dashtkoohi, Constantinos G Hadjipanayis

{"title":"Sodium fluorescein-guided resection of brain metastases: A needed approach or an option? A systematic review and meta-analysis.","authors":"Mohammad Amin Dabbagh Ohadi, Mohammad Dashtkoohi, Mohammad Reza Babaei, Raha Zamani, Mohadese Dashtkoohi, Constantinos G Hadjipanayis","doi":"10.1007/s00701-024-06223-7","DOIUrl":null,"url":null,"abstract":"Purpose: Brain metastases (BM) often leave residual tumors despite having visible margins, which increases the risk of local tumor recurrence and can impact overall patient survival rates. Fluorescence-guided surgery (FGS) utilizing sodium fluorescein (FL) has been reported as an effective technique in recent studies. This study aimed to evaluate the efficacy of FL FGS in improving the extent of resection of brain metastases and its impact on overall survival.Methods: We conducted a systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our primary focus was on gross total resection (GTR). Additionally, we extracted survival data and evaluated the risk of bias using a modified version of the Joanna Briggs Institute critical appraisal tool.Results: The study comprised 970 patients with brain metastases through eight different studies. The study found that patients who underwent FL-guided resection had a significantly higher rate of GTR (OR: 2.02, 95% CI: 1.14-3.56, p = 0.0156, I2 = 41.5%). Additionally, the study concluded that FL-guided resection is associated with better overall survival rates (HR: 0.61, 95%CI: 0.47 0.80, p = 0.0003, I2 = 41.5%).Conclusion: Our research suggests that the use of FL is associated with a higher rate of GTR and improved overall patient survival. None of the studies we reviewed reported significant complications associated with the use of FL in patients.","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurochirurgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00701-024-06223-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Brain metastases (BM) often leave residual tumors despite having visible margins, which increases the risk of local tumor recurrence and can impact overall patient survival rates. Fluorescence-guided surgery (FGS) utilizing sodium fluorescein (FL) has been reported as an effective technique in recent studies. This study aimed to evaluate the efficacy of FL FGS in improving the extent of resection of brain metastases and its impact on overall survival.

Methods: We conducted a systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our primary focus was on gross total resection (GTR). Additionally, we extracted survival data and evaluated the risk of bias using a modified version of the Joanna Briggs Institute critical appraisal tool.

Results: The study comprised 970 patients with brain metastases through eight different studies. The study found that patients who underwent FL-guided resection had a significantly higher rate of GTR (OR: 2.02, 95% CI: 1.14-3.56, p = 0.0156, I2 = 41.5%). Additionally, the study concluded that FL-guided resection is associated with better overall survival rates (HR: 0.61, 95%CI: 0.47 0.80, p = 0.0003, I2 = 41.5%).

Conclusion: Our research suggests that the use of FL is associated with a higher rate of GTR and improved overall patient survival. None of the studies we reviewed reported significant complications associated with the use of FL in patients.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

荧光素钠引导下的脑转移瘤切除术：需要的方法还是一种选择？系统综述与荟萃分析。

目的：脑转移瘤（BM）尽管有明显的边缘，但往往会留下残余肿瘤，这增加了局部肿瘤复发的风险，并会影响患者的总体生存率。最近的研究报道，利用荧光素钠（FL）进行荧光引导手术（FGS）是一种有效的技术。本研究旨在评估荧光引导手术在改善脑转移瘤切除范围方面的疗效及其对总体生存率的影响：我们按照《系统综述和荟萃分析首选报告项目》进行了系统检索。我们主要关注的是全脑切除术（GTR）。此外，我们还提取了生存数据，并使用乔安娜-布里格斯研究所关键评估工具的改进版对偏倚风险进行了评估：该研究包括八项不同研究中的 970 名脑转移患者。研究发现，接受 FL 指导下切除术的患者的 GTR 率明显更高（OR：2.02，95% CI：1.14-3.56，P = 0.0156，I2 = 41.5%）。此外，研究还得出结论，FL 指导下的切除术与更好的总生存率相关（HR：0.61，95%CI：0.47 0.80，P = 0.0003，I2 = 41.5%）：我们的研究表明，FL 的使用与更高的 GTR 率和更高的患者总生存率相关。我们所回顾的研究中，没有一项报告了与患者使用 FL 相关的重大并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.