Histone acetylation regulated by histone deacetylases during spermatogenesis.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-08-12 DOI:10.1111/andr.13723

Xiangying Ou, Juan Yang, Linfeng Yang, Huihong Zeng, Lijian Shao

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Abstract

Background: Physical, chemical, and biological factors in the environment constantly influence in vivo and in vitro biological processes, including diverse histone modifications involved in cancer and metabolism. However, the intricate mechanisms of acetylation regulation remain poorly elucidated. In mammalian spermatogenesis, acetylation plays a crucial role in repairing double-strand DNA breaks, regulating gene transcription, and modulating various signaling pathways.

Results: This review summarizes the histone acetylation sites in the mouse testis and provides a comprehensive overview of how histone acetylation is involved in different stages of spermatogenesis under the regulation by histone deacetylases. The regulatory functions of various class histone deacetylases during spermatogenesis and the crossroad between histone acetylation and other histone modifications are highlighted. It is imperative to understand the mechanisms of histone acetylation regulated by histone deacetylases in spermatogenesis, which facilitates to prevent and treat infertility-related diseases.

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精子发生过程中受组蛋白去乙酰化酶调控的组蛋白乙酰化

背景：环境中的物理、化学和生物因素不断影响着体内和体外的生物过程，包括与癌症和新陈代谢有关的各种组蛋白修饰。然而，乙酰化调控的复杂机制仍未得到充分阐明。在哺乳动物的精子发生过程中，乙酰化在修复双链DNA断裂、调控基因转录和调节各种信号通路方面发挥着至关重要的作用：本综述总结了小鼠睾丸中的组蛋白乙酰化位点，并全面概述了组蛋白乙酰化如何在组蛋白去乙酰化酶的调控下参与精子发生的不同阶段。该研究强调了各类组蛋白去乙酰化酶在精子发生过程中的调控功能，以及组蛋白乙酰化与其他组蛋白修饰之间的交叉作用。了解组蛋白去乙酰化酶在精子发生过程中调控组蛋白乙酰化的机制，有助于预防和治疗与不育相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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