Natural product pharmacology: the British Journal of Pharmacology perspective

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY British Journal of Pharmacology Pub Date : 2024-08-11 DOI:10.1111/bph.17300

Xin Wang, Angelo A. Izzo, Andreas Papapetropoulos, Steve P. H. Alexander, Miriam Cortese-Krott, Dave A. Kendall, Kirill A. Martemyanov, Claudio Mauro, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Péter Ferdinandy

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Abstract

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In this editorial review, we highlight key points from the 2020 British Journal of Pharmacology (BJP) practical guide, which outlines standards for natural products research reports, and provide papers published in BJP between years 2020 to 2023 that demonstrate adherence to these guidelines. Looking ahead, we discuss the potential of chemical proteomics approaches to elucidate natural products mechanisms of action and identify therapeutic targets for future research. By fostering innovation, we aim to advance natural products research and contribute to the development of novel therapeutics that will have a significant impact on healthcare.

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天然产品药理学：英国药理学杂志的观点。

长期以来，天然产物（NPs）一直被用作药物开发的生物活性化合物的丰富来源。最近的技术进步为天然产物研究注入了新的活力，该领域发表的论文数量不断增加就是明证。在这篇社论综述中，我们重点介绍了 2020 年《英国药理学杂志》（BJP）实用指南的要点，该指南概述了天然产物研究报告的标准，并提供了 2020 年至 2023 年期间发表在《英国药理学杂志》上的论文，这些论文证明了这些指南得到了遵守。展望未来，我们将讨论化学蛋白质组学方法在阐明天然产品作用机制和确定未来研究治疗目标方面的潜力。通过促进创新，我们的目标是推动天然产品研究的发展，为开发对医疗保健产生重大影响的新型疗法做出贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.