Effect of Alleviating Preoperative Anxiety on Gastrointestinal Function Recovery After Laparoscopic High Ligation of the Hernia Sac in Children with Indirect Inguinal Hernia.

IF 4.7 2区 医学 Q1 CHEMISTRY, MEDICINAL Drug Design, Development and Therapy Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI:10.2147/DDDT.S461097
Xinyue Chen, Xue Zhang, Ruijia Gao, Yu Huang, Shimeng Mao, Bing Wang, Jiying Feng
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Abstract

Purpose: Anxiety and depression can affect the physiology of the gastrointestinal tract through the brain-gut axis, causing gastrointestinal dysfunction, which is mainly manifested as indigestion, diarrhoea, constipation, or abdominal pain. Preoperative anxiety arises in children due to separation from parents, fear of unfamiliar surroundings and anaesthesia and surgical procedures.To discuss the effect of alleviating preoperative anxiety on postoperative recovery of gastrointestinal function in children with indirect inguinal hernia after laparoscopic high ligation of the hernia sac.

Patients and methods: 90 children with laparoscopic high ligation of the herniated sac in oblique inguinal hernia were randomly divided into control group (Group C) and experimental group (Group M). The Group M was given midazolam oral solution 0.5mg/kg (maximum dose 20mg), and The Group C was given 5% glucose solution with the same dose.Primary outcome was the time to first postoperative defecation and I-FEED scores.The secondary outcomes included mYPAS-SF scores; child sedation scores; child-parent separation scores; parental STAI scores;PHBQ scores;FLACC scores, operative time, and fluid input and surgeon job satisfaction.

Results: Compared with Group C, there was a shorter time to first postoperative defecation (P < 0.05), and lower I-FEED scores on postoperative day 1 (P < 0.05). The mYPAS-SF scores, which were significantly different in Group M at T1, T2, and T3 (P < 0.05), parental STAI scores at S1, child sedation scores and child-parent separation scores in T1, and surgeon job satisfaction between the two groups were significantly different (P < 0.05). There were no statistically significant differences in I-FEED scores on days 2 and 3, PHBQ scores, FLACC scores, operative time, and fluid input between the two groups of children (P > 0.05).

Conclusion: Preoperative application of midazolam oral solution to relieve preoperative anxiety helps to promote the recovery of postoperative gastrointestinal function in children with indirect inguinal hernia and increases the surgeon job satisfaction.

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减轻术前焦虑对间接腹股沟疝气患儿腹腔镜疝囊高位结扎术后胃肠功能恢复的影响
目的:焦虑和抑郁可通过脑-肠轴影响胃肠道的生理功能,引起胃肠功能紊乱,主要表现为消化不良、腹泻、便秘或腹痛。患者和方法:将90名腹腔镜下腹股沟斜疝疝囊高位结扎术患儿随机分为对照组(C组)和实验组(M组)。M组给予咪达唑仑口服溶液0.5mg/kg(最大剂量20mg),C组给予相同剂量的5%葡萄糖溶液,主要结果为术后首次排便时间和I-FEED评分,次要结果包括mYPAS-SF评分、儿童镇静评分、儿童与父母分离评分、父母STAI评分、PHBQ评分、FLACC评分、手术时间、输液量和外科医生工作满意度:与C组相比,C组术后首次排便时间更短(P<0.05),术后第1天I-FEED评分更低(P<0.05)。M组在T1、T2和T3的mYPAS-SF评分、S1的家长STAI评分、T1的儿童镇静评分和儿童与家长分离评分以及两组外科医生的工作满意度均有显著差异(P<0.05)。两组患儿第2天和第3天的I-FEED评分、PHBQ评分、FLACC评分、手术时间和输液量差异无统计学意义(P > 0.05):结论:术前应用咪达唑仑口服溶液缓解术前焦虑有助于促进间接腹股沟疝患儿术后胃肠道功能的恢复,并提高外科医生的工作满意度。
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来源期刊
Drug Design, Development and Therapy
Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY
CiteScore
9.00
自引率
0.00%
发文量
382
审稿时长
>12 weeks
期刊介绍: Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.
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