Relationship Between Retinal Oxygen Saturation and the Severity of Visual Field Damage in Glaucoma.

IF 1.8 4区医学 Q2 OPHTHALMOLOGY Journal of Glaucoma Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI:10.1097/IJG.0000000000002481

Golnoush Mahmoudinezhad, Sasan Moghimi, Eleonora Micheletti, Kelvin H Du, Mohsen Adelpour, Kareem Latif, Evan Walker, Matthew Salcedo, Veronica Rubio, Robert N Weinreb

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Abstract

Précis: Increased oxygen saturation (StO 2 ) was significantly associated with the severity of visual field (VF) damage in patients with glaucoma.

Objective: To investigate the association between retinal StO 2 percentage and the severity of VF loss in glaucoma.

Methods: A total of 198 eyes from 131 patients with glaucoma were included in this cross-sectional study. Participants underwent imaging using ocular oximetry (Zilia) and 24-2 Swedish Interactive Threshold Algorithm standard VF (Carl Zeiss-Meditec). StO 2 (%) was measured at 2 locations of the peripapillary optic nerve head (superotemporal, and inferotemporal). Measurements were reported as the mean of at least 5 measurements in each location. Associations between the severity of VF loss, reported as mean deviation, and StO 2 (%) were calculated.

Results: A total of 198 eyes of 131 patients (mean (95% CI) age, 71.1 (68.9,73.3) years, 68 females (51.9%), and 63 males (48.1%) were analyzed. In univariable analysis, higher StO 2 -0.06 (-0.12, 0.00) was associated with severity in all hemifields ( P = 0.047). Multivariate regression analysis showed that each 1% increase in StO 2 was associated with -0.06 (-0.12, -0.00) dB loss in mean deviation in all hemifields ( P = 0.043). In multivariate regression analysis in the superior hemifields, higher StO 2 -0.07 (-0.16, 0.01) tended to be associated with superior hemifield severity ( P = 0.09).

Conclusions: Retinal oximetry enabled the continuous quantitative measurement of retinal StO 2. Increased StO 2 was significantly associated with the severity of VF damage in patients with glaucoma.

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青光眼视网膜氧饱和度与视野损伤严重程度之间的关系

目的：研究青光眼患者视网膜氧饱和度（StO2）%与视野（VF）缺损严重程度之间的关系：这项横断面研究共纳入了 131 名青光眼患者的 198 只眼睛。参与者使用眼氧仪（Zilia；加拿大魁北克市）和 24-2 SITA 标准 VF（卡尔蔡司-迈迪泰克，圣莱安德罗）进行成像。在视神经头（ONH）周围的两个位置（颞上和颞下）测量血氧饱和度（%）。测量结果以每个位置至少 5 次测量的平均值报告。以平均偏差（MD）报告的 VF 缺失严重程度与 StO2（%）之间的关联进行计算：分析了 131 名患者的 198 只眼睛（平均年龄（95% CI）为 71.1 (68.9,73.3) 岁，其中女性 68 名 [51.9%]，男性 63 名 (48.1%)）。在单变量分析中，较高的 StO2 -0.06 (-0.12, 0.00) 与所有血流场的严重程度相关（P=0.047）。多变量回归分析表明，StO2 每增加 1%，所有半视野的 MD 都会下降 -0.06 (-0.12,-0.00) 分贝（P=0.043）。在上半视野的多变量回归分析中，较高的 StO2 -0.07 (-0.16, 0.01) 往往与上半视野的严重程度相关（P=0.09）：视网膜血氧仪可连续定量测量视网膜 StO2。结论：视网膜血氧仪可连续定量测量视网膜 StO2，StO2 的增加与青光眼患者 VF 损伤的严重程度明显相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Glaucoma 医学-眼科学

CiteScore

4.20

自引率

10.00%

发文量

330

审稿时长

4-8 weeks

期刊介绍： The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.