Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner

IF 4.6 2区 医学 Q1 NEUROSCIENCES Neuropharmacology Pub Date : 2024-08-10 DOI:10.1016/j.neuropharm.2024.110108
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Abstract

Consumption of saturated fat-enriched diets during adolescence has been closely associated with the reduction of hippocampal synaptic plasticity and the impairment of cognitive function. Nevertheless, the effect of long-term intake of these foods has not yet been studied. In the present study, we have investigated the effect of a treatment, lasting for 40 weeks, with a diet enriched in saturated fat (SOLF) on i) spatial learning and memory, ii) hippocampal synaptic transmission and plasticity, and iii) hippocampal gene expression levels in aged male and female mice. Our findings reveal that SOLF has a detrimental impact on spatial memory and synaptic plasticity mechanisms, such as long-term potentiation (LTP), and downregulates Gria1 expression specifically in males. In females, SOLF downregulates the gene expression of Gria1/2/3 and Grin1/2A/2B glutamate receptor subunits as well as some proinflammatory interleukins. These findings highlight the importance of considering sex-specific factors when assessing the long-term effects of high-fat diets on cognition and brain plasticity.

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长期富含饱和脂肪的饮食会以性别依赖的方式损害海马学习和记忆过程。
青少年时期摄入富含饱和脂肪的饮食与海马突触可塑性降低和认知功能受损密切相关。然而,长期摄入这些食物的影响尚未得到研究。在本研究中,我们调查了持续 40 周的富含饱和脂肪(SOLF)饮食对雌雄老年小鼠的以下方面的影响:i)空间学习和记忆;ii)海马突触传递和可塑性;iii)海马基因表达水平。我们的研究结果表明,SOLF 对空间记忆和突触可塑性机制(如长期电位(LTP))有不利影响,并特别下调雄性小鼠的 Gria1 表达。在女性中,SOLF会下调Gria1/2和Grin1/2A/2B谷氨酸受体亚基以及一些促炎性白细胞介素的基因表达。这些发现凸显了在评估高脂饮食对认知和大脑可塑性的长期影响时,考虑性别特异性因素的重要性。
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来源期刊
Neuropharmacology
Neuropharmacology 医学-神经科学
CiteScore
10.00
自引率
4.30%
发文量
288
审稿时长
45 days
期刊介绍: Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).
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