The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Obesity Science & Practice Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI:10.1002/osp4.786
Ilaria Milani, Chiara Gaita, Gloria Guarisco, Marianna Chinucci, Roberta Parisella, Silvia Piroli, Eleonora Bruno, Annunziata Martellucci, Elena De Falco, Fabio Ricci, Antonella Calogero, Frida Leonetti, Danila Capoccia
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Abstract

Background: Type 2 diabetes (T2D) is a risk factor for female breast cancer (FBC). Obesity has also been associated with FBC, also depending on menopausal status. This study aimed to evaluate the impact of obesity and T2D on the development, aggressiveness, and invasiveness of FBC.

Methods: Demographic, clinical, and histopathological data from 335 women with FBC were collected, and analyzed according to weight category (102 normal weight, 117 overweight, and 116 living with obesity) and the presence/absence of T2D.

Results: Age at oncologic diagnosis was not statistically significantly different for body weight; women with overweight or obesity were more likely to have an oncologic diagnosis after menopause than normal weight (p < 0.001). The presence of overweight/obesity and T2D seemed to be associated with a higher incidence of metastasis, recurrence, and triple-negative breast cancer (TNBC) subtype (p < 0.001). Excess body weight was also associated with high histologic grade (G3) (p < 0.005).

Conclusions: These results confirm excess body weight and T2D as unfavorable prognostic factors in terms of the presence of the TNBC subtype, tumor metastasis, recurrence, and aggressiveness (G3 and Ki-67 > 20%). This study highlights the importance of prevention in all women, with early screening, and adequate nutritional programs.

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肥胖、2 型糖尿病与女性乳腺癌之间错综复杂的关系:对 335 名女性的回顾性研究。
背景:2 型糖尿病(T2D)是女性乳腺癌(FBC)的一个危险因素。肥胖也与女性乳腺癌有关,而且还取决于绝经状态。本研究旨在评估肥胖和 T2D 对 FBC 的发展、侵袭性和侵袭性的影响:收集了 335 名女性 FBC 患者的人口统计学、临床和组织病理学数据,并根据体重类别(102 名正常体重、117 名超重和 116 名肥胖)和是否患有 T2D 进行了分析:结果:肿瘤诊断年龄与体重无明显统计学差异;超重或肥胖妇女比正常体重妇女更有可能在绝经后被诊断为肿瘤(p p p 结论:这些结果证实了超重与 T2D 的关系:这些结果证实,在TNBC亚型、肿瘤转移、复发和侵袭性(G3和Ki-67>20%)方面,超重和T2D是不利的预后因素。这项研究强调了通过早期筛查和适当的营养计划对所有女性进行预防的重要性。
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来源期刊
Obesity Science & Practice
Obesity Science & Practice ENDOCRINOLOGY & METABOLISM-
CiteScore
4.20
自引率
4.50%
发文量
73
审稿时长
29 weeks
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