Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Osteoporosis International Pub Date : 2024-12-01 Epub Date: 2024-08-12 DOI:10.1007/s00198-024-07220-3

Kecheng Yuan, Qingyun Liu, Penghui Luo, Changliang Wang, Yufu Zhou, Fulang Qi, Qing Zhang, Xiaoyan Huang, Bensheng Qiu

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Abstract

This study aimed to evaluate the correlation between measuring proton-density fat fraction (PDFF) in bone marrow using multi-echo chemical shift-encoded MRI and osteoporosis, assessing its effectiveness as a biomarker for osteoporosis. A systematic review was conducted by two independent researchers using Cochrane, PubMed, EMBASE, and Web of Science databases up to December 2023. Quality assessments were evaluated using the Cochrane risk of bias tool and the Agency for Healthcare Research and Quality (AHRQ) checklist. Fourteen studies involving 1495 patients were analyzed. The meta-analysis revealed a significant difference in PDFF values between the osteoporosis/osteopenia group and the normal control group, with a mean difference of 11.04 (95% CI: 9.17 to 12.92, Z=11.52, P < 0.00001). Measuring PDFF via MRI shows potential as an osteoporosis biomarker and may serve as a risk factor for osteoporosis. This insight opens new avenues for future diagnostic and therapeutic strategies, potentially improving osteoporosis management and patient care.

Objective: This study aims to assess the correlation between measuring proton-density fat fraction (PDFF) in bone marrow using multi-echo chemical shift-encoded MRI and osteoporosis, evaluating its effectiveness as a biomarker for osteoporosis.

Materials and methods: This systematic review was carried out by two independent researchers using Cochrane, PubMed, EMBASE, and Web of Science databases up to December 2023. Quality assessments were evaluated using the Cochrane risk of bias tool and the Agency for Healthcare Research and Quality (AHRQ) checklist.

Results: Fourteen studies involving 1495 patients were analyzed. The meta-analysis revealed a significant difference in PDFF values between the osteoporosis/osteopenia group and the normal control group, with a (MD = 11.04, 95% CI: 9.17 to 12.92, Z = 11.52, P < 0.00001). Subgroup analyses indicated that diagnostic methods, gender, and echo length did not significantly impact the PDFF-osteoporosis association.

Conclusion: PDFF measurement via MRI shows potential as an osteoporosis biomarker and may serve as a risk factor for osteoporosis. This insight opens new avenues for future diagnostic and therapeutic strategies, potentially improving osteoporosis management and patient care.

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质子密度脂肪分数与骨质疏松症的关系：系统回顾和荟萃分析。

本研究旨在评估使用多回波化学位移编码磁共振成像测量骨髓中质子密度脂肪分数（PDFF）与骨质疏松症之间的相关性，评估其作为骨质疏松症生物标志物的有效性。两名独立研究人员使用 Cochrane、PubMed、EMBASE 和 Web of Science 数据库对截至 2023 年 12 月的研究进行了系统性回顾。质量评估采用 Cochrane 偏倚风险工具和美国医疗保健研究与质量署 (AHRQ) 检查表。对涉及 1495 名患者的 14 项研究进行了分析。荟萃分析显示，骨质疏松症/骨质疏松组与正常对照组的 PDFF 值存在显著差异，平均差异为 11.04（95% CI：9.17 至 12.92，Z=11.52，P 客观）：本研究旨在评估使用多回波化学位移编码磁共振成像测量骨髓中质子密度脂肪分数（PDFF）与骨质疏松症之间的相关性，评价其作为骨质疏松症生物标志物的有效性：本系统综述由两名独立研究人员使用 Cochrane、PubMed、EMBASE 和 Web of Science 数据库（截至 2023 年 12 月）进行。采用 Cochrane 偏倚风险工具和美国医疗保健研究与质量机构 (AHRQ) 的检查表对质量进行评估：对涉及 1495 名患者的 14 项研究进行了分析。荟萃分析显示，骨质疏松症/骨质疏松症组与正常对照组之间的 PDFF 值存在显著差异（MD = 11.04，95% CI：9.17 至 12.92，Z = 11.52，P 结论：通过 MRI 测量 PDFF 显示了其在骨质疏松症/骨质疏松症治疗中的重要作用：通过核磁共振成像测量 PDFF 显示出作为骨质疏松症生物标志物的潜力，并可作为骨质疏松症的风险因素。这一见解为未来的诊断和治疗策略开辟了新的途径，有可能改善骨质疏松症的管理和患者护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoporosis International 医学-内分泌学与代谢

CiteScore

8.10

自引率

10.00%

发文量

224

审稿时长

3 months

期刊介绍： An international multi-disciplinary journal which is a joint initiative between the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA, Osteoporosis International provides a forum for the communication and exchange of current ideas concerning the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition. While focusing on clinical research, the Journal will also accept submissions on more basic aspects of research, where they are considered by the editors to be relevant to the human disease spectrum.