Liver Fatty Acid-binding Protein Is a More Reliable Biomarker for Liver Injury in Nonalcoholic Steatohepatitis than Other Etiologies of Hepatitis.

IF 1.4 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Turkish Journal of Gastroenterology Pub Date : 2024-07-01 DOI:10.5152/tjg.2024.23444

İlker Şen, Şükrü Dumlu

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Abstract

Background/aims: Liver fatty acid-binding protein (LFABP) controls hepatocyte lipid metabolism and can be a biomarker in liver diseases. We compared the correlation of LFABP levels with liver histology in viral hepatitis and nonalcoholic fatty liver disease (NAFLD) and investigated the utility of serum LFABP as a biomarker for liver damage.

Materials and methods: We included 142 patients (60 chronic viral hepatitis B [CHB], 35 chronic viral hepatitis C [CHC], 47 NAFLD) and 40 healthy controls. LFABP levels were determined in all participants, and a liver biopsy was performed on patients. The nonalcoholic steatohepatitis (NASH) activity score (NAS), hepatosteatosis, liver inflammation, and fibrosis were evaluated for NAFLD patients. Ishak's histological scores were used for viral hepatitis. The correlation between LFABP levels and histologic scores was assessed in each group.

Results: Serum LFABP levels in CHB, CHC, NAFLD, and control groups were 2.2, 3.5, 7.6, and 2.1 ng/mL, respectively. LFABP levels were significantly higher in the NAFLD group compared to the control, CHC, and CHB groups. LFABP was significantly higher in the NASH group than in nonalcoholic steatohepatitis, 8 ng/mL and 5.4 ng/mL, respectively (P = .001). In the NAFLD group, LFABP levels showed a moderate positive correlation with NAS score (r = 0.58, P <.001), ballooning degeneration (r = 0.67, P <.001), and lobular inflammation (r = 0.62, P <.001). A logistic regression study showed that the level of LFABP was predictive of NASH independent of age, gender, homeostasis model of IR, body mass index, aspartate aminotransferase, and alanine aminotransferase (OR = 1.869, P = .01).

Conclusion: LFABP specifically correlates with liver histology in NAFLD compared to viral hepatitis. Additionally, it can distinguish NASH from simple steatosis. LFABP may be a valuable biomarker for hepatocyte injury in NASH.

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肝脂肪酸结合蛋白是非酒精性脂肪性肝炎肝损伤比其他病因肝炎更可靠的生物标志物

背景/目的：肝脂肪酸结合蛋白（LFABP）控制肝细胞脂质代谢，可作为肝脏疾病的生物标志物。我们比较了病毒性肝炎和非酒精性脂肪肝（NAFLD）中 LFABP 水平与肝组织学的相关性，并研究了血清 LFABP 作为肝损伤生物标志物的效用：我们纳入了 142 名患者（60 名慢性乙型病毒性肝炎 [CHB]、35 名慢性丙型病毒性肝炎 [CHC]、47 名非酒精性脂肪肝患者）和 40 名健康对照者。对所有参与者的 LFABP 水平进行了测定，并对患者进行了肝活检。对非酒精性脂肪肝患者的非酒精性脂肪性肝炎（NASH）活动度评分（NAS）、肝脂肪变性、肝脏炎症和纤维化进行了评估。病毒性肝炎采用伊萨克组织学评分。评估了各组患者 LFABP 水平与组织学评分之间的相关性：结果：CHB、CHC、NAFLD 和对照组的血清 LFABP 水平分别为 2.2、3.5、7.6 和 2.1 纳克/毫升。与对照组、CHC 组和 CHB 组相比，NAFLD 组的 LFABP 水平明显更高。NASH组的LFABP明显高于非酒精性脂肪性肝炎组，分别为8纳克/毫升和5.4纳克/毫升（P = .001）。在非酒精性脂肪性肝病组中，LFABP 水平与 NAS 评分呈中度正相关（r = 0.58，P 结论：LFABP 与非酒精性脂肪性肝病的相关性较高：与病毒性肝炎相比，LFABP 与非酒精性脂肪肝的肝组织学有特殊的相关性。此外，它还能区分非酒精性脂肪肝和单纯性脂肪变性。LFABP 可能是检测 NASH 中肝细胞损伤的一种有价值的生物标志物。

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来源期刊

Turkish Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

1.90

自引率

0.00%

发文量

127

审稿时长

6 months

期刊介绍： The Turkish Journal of Gastroenterology (Turk J Gastroenterol) is the double-blind peer-reviewed, open access, international publication organ of the Turkish Society of Gastroenterology. The journal is a bimonthly publication, published on January, March, May, July, September, November and its publication language is English. The Turkish Journal of Gastroenterology aims to publish international at the highest clinical and scientific level on original issues of gastroenterology and hepatology. The journal publishes original papers, review articles, case reports and letters to the editor on clinical and experimental gastroenterology and hepatology.