Functional measures and AD biomarkers among Hispanic and White non-Hispanic older adults.

IF 4 Q1 CLINICAL NEUROLOGY Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-08-10 eCollection Date: 2024-07-01 DOI:10.1002/dad2.12632

Miriam J Rodriguez, Lisandra Mendoza, Patricia Garcia, Andres Duarte, Dilianna Padron, Michael Marsiske, Jacob Fiala, Joanna Gonzalez, Ranjan Duara

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Abstract

Introduction: Poorer baseline functioning is associated with long-term cognitive decline among Hispanic older adults, but little is known about associations of these factors with Alzheimer's disease (AD) neuroimaging biomarkers.

Methods: A total of 461 Hispanic and White non-Hispanic (NHW) older adults who are cognitively normal (n = 76), had impaired cognition without mild cognitive impairment (MCI) (n = 41), or carried a diagnosis of MCI (n = 253) or dementia (n = 91) completed neuropsychological and functional assessment, genetic testing, and brain magnetic resonance imaging (MRI). Structural equation modeling (SEM) was used to examine predictive associations between functional and cognitive measures of AD neuroimaging biomarkers.

Results: MRI volumes significantly predicted functional limitations in both groups. Sex and amyloid load significantly predicted functional limitations among the Hispanic group only. Years of education and MRI regional volume were the strongest predictors of cognition among both groups.

Discussion: Results indicate that functional performance is associated with early AD biomarkers among Hispanic older adults. Clinical implications are discussed.

Highlights: The current study addresses health disparities in Alzheimer's disease (AD) and related dementia assessment among Hispanics by identifying measures sensitive to early AD biomarkers.Associations of functional measures with AD genetic and neuroimaging biomarkers revealed that similarities in these associations exist between Hispanic and White non-Hispanic individuals, but biological sex and amyloid load significantly predicted functional limitations among the Hispanic group only.These results have clinical implications for physicians who treat Hispanic AD patients and indicate that when compared to traditional diagnostic assessments, functional assessments may better aid in AD diagnostic precision among Hispanics.

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西班牙裔和非西班牙裔白人老年人的功能测量和注意力缺失症生物标志物。

介绍：在西班牙裔老年人中，较差的基线功能与长期认知能力下降有关，但这些因素与阿尔茨海默病（AD）神经影像生物标志物之间的关系却鲜为人知：共有 461 名西班牙裔和非西班牙裔白人（NHW）老年人完成了神经心理和功能评估、基因测试和脑磁共振成像（MRI）。这些老年人认知正常（n = 76）、认知受损但无轻度认知障碍（MCI）（n = 41）或被诊断为 MCI（n = 253）或痴呆（n = 91）。研究人员使用结构方程模型（SEM）研究了AD神经影像生物标志物的功能和认知指标之间的预测关联：结果：核磁共振成像体积对两组患者的功能限制都有明显的预测作用。性别和淀粉样蛋白负荷仅对西班牙裔组的功能限制有显著预测作用。受教育年限和磁共振成像区域体积是两组患者认知能力的最强预测因子：讨论：研究结果表明，西班牙裔老年人的功能表现与早期 AD 生物标志物有关。重点：本研究通过确定对早期阿兹海默症生物标志物敏感的测量指标，解决了阿兹海默症（AD）和相关痴呆症评估在西班牙裔中的健康差异问题。功能测量指标与阿兹海默症基因和神经影像生物标志物的关联显示，西班牙裔和非西班牙裔白人之间存在相似之处，但生理性别和淀粉样蛋白负荷仅对西班牙裔群体的功能限制有显著预测作用。这些结果对治疗西语裔注意力缺失症患者的医生具有临床意义，并表明与传统的诊断评估相比，功能评估可以更好地帮助西语裔准确诊断注意力缺失症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.