Preliminary Study of Micronucleus Frequencies and Responses in Thyroid Cancer Patients After Treatment with 131I Therapy

IF 0.6 Q4 NUCLEAR SCIENCE & TECHNOLOGY Atom Indonesia Pub Date : 2024-08-08 DOI:10.55981/aij.2024.1409

I. K. H. Basri, Y. Lusiyanti, D. Ramadhani, D. Tetriana, A. R. Dewi, S. Purnami, V. A. Suvivan, M. R. A. Gani, T. Kisnanto

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Abstract

Radioiodine has become the most widely used to treat an overactive thyroid (hyperthyroidism) and thyroid cancer worldwide. The present research aimed to study the association between micronuclei (MN) frequencies, and follow-up responses after treating thyroid cancer patients with iodium-131(131I). The detection of the MNs assay was carried out by Giemsa staining from lymphocytes obtained from twenty-four thyroid cancer patients one week after receiving 131I treatment at Dharmais Cancer Center Hospital, Jakarta, Indonesia. Follow-up for clinical and laboratory responses grouped into good (stable) and bad (progressive, refractory, and dropout patients) responses, was observed one and six months after treatment. All patients received radioiodine with an activity dose of 30 - 200 μCi. The mean MN frequency in the good response group was 14.22, and that of bad response patients was 17.22. There was no statistically significant difference in MN frequency (p>0.05) between the two groups of patients after six months of treatment.

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甲状腺癌患者接受 131I 治疗后微核频率和反应的初步研究

在全球范围内，放射性碘已成为治疗甲状腺功能亢进（甲亢）和甲状腺癌最广泛的药物。本研究旨在探讨微核（MN）频率与碘化钠-131（131I）治疗甲状腺癌患者的后续反应之间的关联。在印度尼西亚雅加达的达迈斯癌症中心医院，24 名甲状腺癌患者在接受 131I 治疗一周后，对其淋巴细胞进行 Giemsa 染色，检测 MNs。在治疗后 1 个月和 6 个月，对患者的临床和实验室反应进行随访观察，反应分为良好（稳定）和不良（进展期、难治期和辍学患者）两类。所有患者都接受了活性剂量为 30 - 200 μCi 的放射性碘治疗。反应良好组患者的平均 MN 频率为 14.22，反应不良组患者的平均 MN 频率为 17.22。治疗 6 个月后，两组患者的 MN 频率差异无统计学意义（P>0.05）。

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来源期刊

Atom Indonesia NUCLEAR SCIENCE & TECHNOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The focus of Atom Indonesia is research and development in nuclear science and technology. The scope of this journal covers experimental and analytical research in nuclear science and technology. The topics include nuclear physics, reactor physics, radioactive waste, fuel element, radioisotopes, radiopharmacy, radiation, and neutron scattering, as well as their utilization in agriculture, industry, health, environment, energy, material science and technology, and related fields.