The PVT1, HULC, and HOTTIP expression changes due to treatment in Diffuse Large B-cell lymphoma

Milad Shahsavari, Sedigheh Arbabian, Farzaneh Hosseini, Mohamad Reza Razavi
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Abstract

Diffuse large B-cell lymphoma is the most common histological subtype of non-Hodgkin’s lymphomas. It is an aggressive malignancy that displays great heterogeneity in morphology, genetics, biological behavior and treatment response owing to chromatin remodeling and epigenetics.
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弥漫大 B 细胞淋巴瘤治疗引起的 PVT1、HULC 和 HOTTIP 表达变化
弥漫大B细胞淋巴瘤是非霍奇金淋巴瘤中最常见的组织学亚型。它是一种侵袭性恶性肿瘤,由于染色质重塑和表观遗传学的影响,在形态、遗传学、生物学行为和治疗反应方面表现出极大的异质性。
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