Traveling Wavefronts to a Model of Precursor and Differentiated Cells: Impacting Parameter-Structure Transition from Monostable to Bistable, and from Monotone to Non-monotone

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-06 DOI:10.1007/s10884-024-10384-5
Yuanxi Yue, Chunhua Ou
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Abstract

This paper provides a novel analysis of the rich and complex propagation dynamics to a model of precursor and differentiated cells, with the appearance of non-isolated equilibria on a line in the phase space. We established the existence of traveling waves in the monostable monotone case by means of continuation argument via perturbation in a weighted functional space, by applying the abstract implicit function theorem. We proved necessary and sufficient conditions of the minimal wave speed selection and showed the existence of the transition (turning point) \(k^*\) for the minimal wave speed when the parameters \(\lambda \) and \(\gamma \) are fixed. Two explicit estimates about \(k^*\) were given by the easy-to-apply theorem we derived. We investigated the decay rate of the minimal traveling wave as \(z\rightarrow \infty \) in terms of the value of k. We further proved the existence of non-negative wavefronts in the monostable non-monotone case and found that the minimal wave speed is always linearly selected. Finally in the bistable monotone case, the existence and uniqueness of bistable traveling waves were proved via constructing an auxiliary parabolic non-local equation.

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前体细胞和分化细胞模型的移动波面:从单稳态到双稳态以及从单调到非单调的参数-结构转变的影响
本文对前体和分化细胞模型的丰富而复杂的传播动力学进行了新颖的分析,在相空间的一条线上出现了非孤立的平衡点。我们运用抽象隐函数定理,通过加权函数空间中的扰动进行延续论证,从而确定了单稳单调情况下行波的存在性。我们证明了最小波速选择的必要条件和充分条件,并证明了当参数 \(\lambda \) 和 \(\gamma \) 固定时,最小波速的过渡(转折点) \(k^*\) 的存在。通过我们得出的易于应用的定理,给出了关于 \(k^*\) 的两个明确估计值。我们进一步证明了在单稳态非单调情况下存在非负波面,并发现最小波速总是线性选择的。最后,在双稳态单调情况下,通过构建一个辅助抛物线非局部方程,证明了双稳态行波的存在性和唯一性。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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