{"title":"Urea-based DES as an amine source to access nitrogen-containing heterocycles","authors":"Sundararajan Suresh, Fazlur Rahman Nawaz Khan","doi":"10.1016/j.tetlet.2024.155224","DOIUrl":null,"url":null,"abstract":"<div><p>Herein, we report a urea-based DES that acts as an amine source in the synthesis of <em>N</em>-substituted styryl quinazolinone from anthranilic acid <em>via N</em>-acylation, cyclization, and subsequent sp<sup>3</sup> C<img>H functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"148 ","pages":"Article 155224"},"PeriodicalIF":1.5000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003198","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, we report a urea-based DES that acts as an amine source in the synthesis of N-substituted styryl quinazolinone from anthranilic acid via N-acylation, cyclization, and subsequent sp3 CH functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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