Extreme-value analysis in nano-biological systems: Applications and Implications

Abstract

Extreme value analysis (EVA) is a statistical method that studies the properties of extreme values of datasets, crucial for fields like engineering, meteorology, finance, insurance, and environmental science. EVA models extreme events using distributions such as Fr\'echet, Weibull, or Gumbel, aiding in risk prediction and management. This review explores EVA's application to nanoscale biosystems. Traditionally, biological research focuses on average values from repeated experiments. However, EVA offers insights into molecular mechanisms by examining extreme data points. We introduce EVA's concepts with simulations and review its use in studying motor protein movements within cells, highlighting the importance of in vivo analysis due to the complex intracellular environment. We suggest EVA as a tool for extracting motor proteins' physical properties in vivo and discuss its potential in other biological systems. While EVA's use in nanoscale biological systems is limited, it holds promise for uncovering hidden properties in extreme data, promoting its broader application in life sciences.