Medicinal Applications and Prospects of Tetra- and Tripyrrole Compounds

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2024-08-06 DOI:10.1134/S1990750823600590

E. O. Moiseeva, E. A. Gorbunova, T. V. Dubinina

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Abstract

This review is devoted to some areas of medicinal application of pyrrole-containing macroheterocycles. Two main application areas were discussed: treatment and imaging. The treatment part is divided into anticancer and photodynamic antimicrobial chemotherapy. Novel hybrid and encapsulated photosensitizers were concerned. Successful attempts to inactivate various viruses, including avian influenza H5N8 and SARS-CoV-2, are discussed. Imaging aspects include fluorescence imaging and magnetic resonance imaging. The fluorescence imaging part concerns not only the traditional porphyrin/phthalocyanine ligand fluorescence, but also the near-infrared emission of the central lanthanide ion. The review examines the areas of application of new promising tripyrrole photosensitizers—boron subphthalocyanines. Previously, these compounds attracted the attention of researchers only as materials for organic electronics. However, these compounds are currently considered promising candidates for photodynamic therapy.

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四吡咯和三吡咯化合物的药用应用与前景

摘要本综述专门讨论含吡咯的大杂环的一些药物应用领域。主要讨论了两个应用领域：治疗和成像。治疗部分分为抗癌和光动力抗菌化疗。新型混合光敏剂和封装光敏剂受到关注。讨论了灭活各种病毒（包括禽流感 H5N8 和 SARS-CoV-2）的成功尝试。成像方面包括荧光成像和磁共振成像。荧光成像部分不仅涉及传统的卟啉/酞菁配体荧光，还涉及中心镧系离子的近红外发射。本综述探讨了新型三吡咯光敏剂--硼亚酞菁的应用领域。以前，这些化合物仅作为有机电子材料引起研究人员的注意。不过，这些化合物目前被认为是有希望用于光动力疗法的候选化合物。

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.