Efficient Green Synthesis and Characterization of Benzil and its Derivatives Using Microwave Irradiation

IF 0.7 4区 化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2024-08-07 DOI:10.2174/0115701786308700240801062008
Krina Patel, Drashti Shah, Dev Jani, Neel Savaliya, Dharti Patel, Ashish Shah, Pinkal Patel, Ashish Patel
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Abstract

: The main aim of the present work was to conduct the one-pot microwave-assisted green synthesis of benzil and its derivatives. Benzil is acknowledged as a pivotal scaffold in the realm of medicinal and organic chemistry, owing to its extensive utilities. Due to the various merits of the green technology approach compared to classical methodology and the provision of sustainable chemistry, this reaction has received renewed interest for preparing benzil derivatives in an environmentally friendly manner with improved yields. We have, herein, presented a highly efficient route for the synthesis of benzil derivatives utilizing acetophenone and benzene derivatives as primary substrates. Notably, this synthesis obviates the necessity for any potentially hazardous catalyst and employs microwave irradiation and iodine green oxidant to facilitate the reaction. All synthesized compounds were characterized by spectroscopic techniques, such as IR, 1H NMR, and mass spectrometry. A green and efficient microwave-assisted synthesis methodology for benzil and its derivatives has been developed using iodine green oxidant. This approach has yielded the desired benzil derivatives with remarkable efficiency, achieving yields ranging from 91% to 97% within a short time of 10-15 minutes; the derivatives have been characterized using spectral techniques, viz., IR, 1H NMR, and mass spectrometry. It is noteworthy that the entire reaction optimization process has been conducted in an environmentally friendly manner, thereby exemplifying a synthetic methodology being both environmentally sustainable and economically viable, compared to conventional techniques.
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利用微波辐照对苯齐及其衍生物进行高效绿色合成和表征
:本研究的主要目的是进行苯偶酰及其衍生物的单锅微波辅助绿色合成。苯偶酰因其广泛的用途而被公认为是药物和有机化学领域的关键支架。由于绿色技术方法与传统方法相比具有各种优点,而且提供了可持续化学,因此这种反应在以环境友好的方式制备苯偶酰衍生物并提高产率方面再次受到关注。在此,我们提出了一条利用苯乙酮和苯衍生物作为主要底物合成苯偶姻衍生物的高效路线。值得注意的是,这种合成方法无需使用任何潜在危险的催化剂,并采用微波辐照和碘绿氧化剂来促进反应。所有合成化合物都通过红外光谱、1H NMR 和质谱等光谱技术进行了表征。利用碘绿氧化剂开发了一种绿色高效的微波辅助合成苯偶姻及其衍生物的方法。这种方法能在 10-15 分钟的短时间内高效地合成出所需的苯偶酰衍生物,产率从 91% 到 97%不等;衍生物的特征已通过光谱技术(即红外光谱、1H NMR 和质谱分析)确定。值得注意的是,整个反应优化过程都是以对环境友好的方式进行的,因此与传统技术相比,这种合成方法既具有环境可持续性,又具有经济可行性。
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来源期刊
Letters in Organic Chemistry
Letters in Organic Chemistry 化学-有机化学
CiteScore
1.30
自引率
12.50%
发文量
135
审稿时长
7 months
期刊介绍: Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.
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