Insight into the Various Synthetic Approaches of 1,3,4 and 1,2,4-Oxadiazole and its Derivatives, Along with their Remarkable Biological Activities

IF 0.7 4区 化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2024-08-08 DOI:10.2174/0115701786318560240723060417
Sadhana Sharma, Chandana Majee, Rupa Mazumder, Kavita Rana, Swrupanjali Padhi, Avijit Mazumder, Saumya Das, Pankaj Kumar Tyagi, Sachin Kumar Singh
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Abstract

: Oxadiazole is an organic compound featuring a heterocyclic ring housing carbon, oxygen, and nitrogen atoms. Due to their heightened stability in biological environments, oxadiazole rings exhibit significant biological activities, effectively addressing health challenges like infectious diseases and chronic conditions in medicinal chemistry. The main objective of this review is to discuss various synthetic approaches related to oxadiazole and its derivatives, along with their biological activities. The diverse reactivity positions oxadiazole as a valuable building block in organic synthesis, with derivatives exhibiting promising pharmacological activities. It involves a systematic literature review, critical analysis, and synthesis of existing research. This review comprises the everexpanding chemical knowledge but also holds significant implications for drug development. The various synthetic approaches, such as Suzuki-Miyaura, Stille coupling [3+2] cycloaddition reaction, and many more methods used for the synthesis of oxadiazole through different schemes, have been discussed thoroughly. This review also concisely associated the pharmacological activities of new oxadiazole and its derivatives, such as prenoxdiazine, dapagliflozin, nesapidil, pleconaril, and so on. This review highlights the importance of continued research into the structure-activity relationships of oxadiazole derivatives, paving the way for developing novel and more potent therapeutic agents.
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深入了解 1,3,4 和 1,2,4- 恶二唑及其衍生物的各种合成方法及其显著的生物活性
:噁二唑是一种有机化合物,具有一个包含碳、氧和氮原子的杂环。由于其在生物环境中的高度稳定性,恶二唑环具有显著的生物活性,可有效解决药物化学中的传染性疾病和慢性疾病等健康难题。本综述的主要目的是讨论与噁二唑及其衍生物有关的各种合成方法及其生物活性。噁二唑具有多种反应活性,是有机合成的重要构件,其衍生物具有良好的药理活性。这涉及到对现有研究的系统性文献回顾、批判性分析和综合。这篇综述不仅包含了不断扩展的化学知识,而且对药物开发具有重要意义。本综述深入讨论了各种合成方法,如 Suzuki-Miyaura、Stille 偶联 [3+2] 环加成反应,以及更多通过不同方案合成噁二唑的方法。本综述还简明扼要地介绍了新型噁二唑及其衍生物的药理活性,如普诺地嗪、达帕利嗪、奈沙地尔、哌氯地尔等。这篇综述强调了继续研究噁二唑衍生物结构-活性关系的重要性,为开发新型和更有效的治疗药物铺平了道路。
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来源期刊
Letters in Organic Chemistry
Letters in Organic Chemistry 化学-有机化学
CiteScore
1.30
自引率
12.50%
发文量
135
审稿时长
7 months
期刊介绍: Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.
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