Zinc Nanostructure: A Short Review on Phytochemicals-Mediated Biogenic Synthesis and Its Anti-Inflammatory Effects

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Journal of Cluster Science Pub Date : 2024-08-07 DOI:10.1007/s10876-024-02681-2

Omilla Ragavan, Muhammad Nazrul Hakim Abdullah, Lai Yen Fong, Vuanghao Lim, Yoke Keong Yong

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Abstract

Chronic inflammation underpins many severe diseases, often requiring anti-inflammatory drugs that can have adverse effects. Medicinal herbs offer an alternative but suffer from poor solubility, limiting their efficacy. Nanotechnology, particularly zinc oxide nanoparticles (ZnO NPs), presents a promising solution to enhance the therapeutic potential of herbal compounds. This review examines the nature and benefits of ZnO NPs in drug delivery systems compared to other nanomaterials. It highlights the advantages of biogenic synthesis of ZnO NPs, detailing the eco-friendly formation mechanisms and common characterization methods. The anti-inflammatory effects of biosynthesized ZnO NPs over the last five years are comprehensively reviewed, with insights into their mechanisms of action. Additionally, the pharmacokinetic and toxicokinetic profiles of ZnO NPs are explored to understand their biokinetics post-drug release. In conclusion, biogenically synthesized ZnO NPs enhance the bioavailability of medicinal plant compounds, offering a compelling alternative for treating inflammatory conditions.

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锌纳米结构：植物化学物质介导的生物合成及其抗炎作用简评

慢性炎症是许多严重疾病的基础，通常需要服用消炎药，但消炎药可能会产生不良影响。药用草本植物提供了另一种选择，但其溶解性差，限制了药效。纳米技术，尤其是氧化锌纳米粒子（ZnO NPs），为提高草药化合物的治疗潜力提供了一种前景广阔的解决方案。与其他纳米材料相比，本综述探讨了 ZnO NPs 在给药系统中的性质和优势。它强调了生物合成氧化锌氮氧化物的优势，详细介绍了生态友好型的形成机制和常见的表征方法。全面回顾了过去五年中生物合成 ZnO NPs 的抗炎效果，并深入探讨了其作用机制。此外，还探讨了氧化锌氮氧化物的药代动力学和毒代动力学特征，以了解其药物释放后的生物动力学。总之，生物合成的氧化锌氮氧化物提高了药用植物化合物的生物利用度，为治疗炎症提供了一种令人信服的替代方法。

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.