Low-frequency Raman spectrum of methamphetamine hydrochloride and its alterations induced by impurities

IF 2.6 3区医学 Q2 CHEMISTRY, ANALYTICAL Forensic Chemistry Pub Date : 2024-08-03 DOI:10.1016/j.forc.2024.100601

Hiroki Segawa, Yuko T. Iwata, Yuki Okada, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori

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Abstract

Methamphetamine is one of the most abused drugs worldwide. Forensic laboratories have developed various methods to analyze methamphetamine for identifying and comparing seizures. These methods basically focus on the physicochemical properties of the methamphetamine molecule. Because methamphetamine is commonly distributed in its hydrochloride salt form, information on the crystalline state of methamphetamine could give new insight for forensic drug analysis. To grasp this information, we applied low-frequency Raman spectroscopy to methamphetamine hydrochloride. A laboratory-built low-frequency Raman microspectrometer was used for measuring low-frequency Raman spectra of optically pure and racemic methamphetamine hydrochloride. A mixture of methamphetamine hydrochloride with dimethyl sulfone, which is frequently added as a diluent to illicit methamphetamines, was also measured. An ab initio calculation was performed to assign peaks in the low-frequency spectra. The phonon modes of methamphetamine hydrochloride, and their changes induced by impurities are discussed. To the best of our knowledge, this is the first reported application of low-frequency Raman spectroscopy technique to methamphetamine hydrochloride.

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盐酸甲基苯丙胺的低频拉曼光谱及其由杂质引起的变化

甲基苯丙胺是全球滥用最严重的毒品之一。法医实验室开发了各种方法来分析甲基苯丙胺，以识别和比较缉获量。这些方法基本上侧重于甲基苯丙胺分子的物理化学特性。由于甲基苯丙胺通常以盐酸盐形式分布，因此有关甲基苯丙胺结晶状态的信息可为法医毒品分析提供新的见解。为了掌握这些信息，我们对盐酸甲基苯丙胺进行了低频拉曼光谱分析。我们使用实验室自制的低频拉曼显微光谱仪测量了光学纯品和外消旋盐酸甲基苯丙胺的低频拉曼光谱。此外，还测量了盐酸甲基苯丙胺与二甲砜的混合物，二甲砜经常作为稀释剂添加到非法甲基苯丙胺中。对低频光谱中的峰值进行了 ab initio 计算。讨论了盐酸甲基苯丙胺的声子模式及其由杂质引起的变化。据我们所知，这是首次报道将低频拉曼光谱技术应用于盐酸甲基苯丙胺。

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来源期刊

Forensic Chemistry CHEMISTRY, ANALYTICAL-

CiteScore

5.70

自引率

14.80%

发文量

审稿时长

46 days

期刊介绍： Forensic Chemistry publishes high quality manuscripts focusing on the theory, research and application of any chemical science to forensic analysis. The scope of the journal includes fundamental advancements that result in a better understanding of the evidentiary significance derived from the physical and chemical analysis of materials. The scope of Forensic Chemistry will also include the application and or development of any molecular and atomic spectrochemical technique, electrochemical techniques, sensors, surface characterization techniques, mass spectrometry, nuclear magnetic resonance, chemometrics and statistics, and separation sciences (e.g. chromatography) that provide insight into the forensic analysis of materials. Evidential topics of interest to the journal include, but are not limited to, fingerprint analysis, drug analysis, ignitable liquid residue analysis, explosives detection and analysis, the characterization and comparison of trace evidence (glass, fibers, paints and polymers, tapes, soils and other materials), ink and paper analysis, gunshot residue analysis, synthetic pathways for drugs, toxicology and the analysis and chemistry associated with the components of fingermarks. The journal is particularly interested in receiving manuscripts that report advances in the forensic interpretation of chemical evidence. Technology Readiness Level: When submitting an article to Forensic Chemistry, all authors will be asked to self-assign a Technology Readiness Level (TRL) to their article. The purpose of the TRL system is to help readers understand the level of maturity of an idea or method, to help track the evolution of readiness of a given technique or method, and to help filter published articles by the expected ease of implementation in an operation setting within a crime lab.