Francesca Rovida, Marino Faccini, Carla Molina Grané, Irene Cassaniti, Sabrina Senatore, Eva Rossetti, Giuditta Scardina, Manuela Piazza, Giulia Campanini, Daniele Lilleri, Stefania Paolucci, Guglielmo Ferrari, Antonio Piralla, Francesco Defilippo, Davide Lelli, Ana Moreno, Luigi Vezzosi, Federica Attanasi, Soresini Marzia, Barozzi Manuela, Lorenzo Cerutti, Stefano Paglia, Angelo Regazzetti, Maurilia Marcacci, Guido Di Donato, Marco Farioli, Mattia Manica, Piero Poletti, Antonio Lavazza, Maira Bonini, Stefano Merler, Fausto Baldanti, Danilo Cereda, Lombardy Dengue network
{"title":"The 2023 Dengue Outbreak in Lombardy, Italy: A One-Health Perspective","authors":"Francesca Rovida, Marino Faccini, Carla Molina Grané, Irene Cassaniti, Sabrina Senatore, Eva Rossetti, Giuditta Scardina, Manuela Piazza, Giulia Campanini, Daniele Lilleri, Stefania Paolucci, Guglielmo Ferrari, Antonio Piralla, Francesco Defilippo, Davide Lelli, Ana Moreno, Luigi Vezzosi, Federica Attanasi, Soresini Marzia, Barozzi Manuela, Lorenzo Cerutti, Stefano Paglia, Angelo Regazzetti, Maurilia Marcacci, Guido Di Donato, Marco Farioli, Mattia Manica, Piero Poletti, Antonio Lavazza, Maira Bonini, Stefano Merler, Fausto Baldanti, Danilo Cereda, Lombardy Dengue network","doi":"arxiv-2408.04768","DOIUrl":null,"url":null,"abstract":"Introduction. Here we reported the virological, entomological and\nepidemiological characteristics of the large autochthonous outbreak of dengue\n(DENV) occurred in a small village of the Lombardy region (Northern Italy)\nduring summer 2023. Methods. After the diagnosis of the first autochthonous case on 18 August\n2023, public health measures, including epidemiological investigation and\nvector control measures, were carried out. A serological screening for DENV\nantibodies detection was offered to the population. In the case of positive\nDENV IgM, a second sample was collected to detect DENV RNA and verify\nseroconversion. Entomological and epidemiological investigations were also\nperformed. A modeling analysis was conducted to estimate the dengue generation\ntime, transmission potential, distance of transmission, and assess diagnostic\ndelays. Results. Overall, 416 subjects participated to the screening program and 20\nwere identified as DENV-1 cases (15 confirmed and 5 probable). In addition,\nDENV-1 infection was diagnosed in 24 symptomatic subjects referred to the local\nEmergency Room Department for suggestive symptoms and 1 case was identified\nthrough blood donation screening. The average generation time was estimated to\nbe 18.3 days (95% CI: 13.1-23.5 days). R0 was estimated at 1.31 (95% CI:\n0.76-1.98); 90% of transmission occurred within 500m. Entomological\ninvestigations performed in 46 pools of mosquitoes revealed the presence of\nonly one positive pool for DENV-1. Discussion. This report highlights the importance of synergic surveillance,\nincluding virological, entomological and public health measures to control the\nspread of arboviral infections.","PeriodicalId":501044,"journal":{"name":"arXiv - QuanBio - Populations and Evolution","volume":"93 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Populations and Evolution","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2408.04768","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction. Here we reported the virological, entomological and
epidemiological characteristics of the large autochthonous outbreak of dengue
(DENV) occurred in a small village of the Lombardy region (Northern Italy)
during summer 2023. Methods. After the diagnosis of the first autochthonous case on 18 August
2023, public health measures, including epidemiological investigation and
vector control measures, were carried out. A serological screening for DENV
antibodies detection was offered to the population. In the case of positive
DENV IgM, a second sample was collected to detect DENV RNA and verify
seroconversion. Entomological and epidemiological investigations were also
performed. A modeling analysis was conducted to estimate the dengue generation
time, transmission potential, distance of transmission, and assess diagnostic
delays. Results. Overall, 416 subjects participated to the screening program and 20
were identified as DENV-1 cases (15 confirmed and 5 probable). In addition,
DENV-1 infection was diagnosed in 24 symptomatic subjects referred to the local
Emergency Room Department for suggestive symptoms and 1 case was identified
through blood donation screening. The average generation time was estimated to
be 18.3 days (95% CI: 13.1-23.5 days). R0 was estimated at 1.31 (95% CI:
0.76-1.98); 90% of transmission occurred within 500m. Entomological
investigations performed in 46 pools of mosquitoes revealed the presence of
only one positive pool for DENV-1. Discussion. This report highlights the importance of synergic surveillance,
including virological, entomological and public health measures to control the
spread of arboviral infections.