{"title":"A concise protocol for the synthesis of 2-alkenylindoles through [4 + 1] annulation of aminobenzyl phosphonium salts with acrylaldehydes†","authors":"","doi":"10.1039/d4gc02859g","DOIUrl":null,"url":null,"abstract":"<div><p>A [4 + 1] annulation protocol is developed for the synthesis of various 2-alkenylindole derivatives starting from aminobenzyl phosphonium salts and cinnamaldehydes. In this process, the reaction proceeds efficiently without the usage of any metal catalysts or base, and features available starting materials, a broad substrate scope, excellent yields and simple reaction conditions.</p></div>","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":null,"pages":null},"PeriodicalIF":9.3000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1463926224007131","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A [4 + 1] annulation protocol is developed for the synthesis of various 2-alkenylindole derivatives starting from aminobenzyl phosphonium salts and cinnamaldehydes. In this process, the reaction proceeds efficiently without the usage of any metal catalysts or base, and features available starting materials, a broad substrate scope, excellent yields and simple reaction conditions.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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