Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder

Psychiatry research communications Pub Date : 2024-09-01 Epub Date: 2024-08-03 DOI:10.1016/j.psycom.2024.100188

Nagahide Takahashi , Tomoko Nishimura , Akemi Okumura , Taeko Harada , Toshiki Iwabuchi , Md Shafiur Rahman , Pi-Hua Liu , Gwo-Tsann Chuang , Yi-Cheng Chang , Yoko Nomura , Kenji J. Tsuchiya

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Abstract

Sleep problems are common in individuals with ADHD; however, the exact underlying mechanism is unknown. I Data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (N = 27,076), the Taiwan Biobank (N = 2373) and the Hamamatsu Birth Cohort for Mothers and Children (N = 726) were used for analysis. Linkage disequilibrium score-based genetic correlation showed a genetic correlation between melatonin secretion and ADHD diagnosis (r_g[SD] = -0.134 [0.012], P < 0.001). Polygenic risk score analyses revealed that genetic variants related to melatonin secretion were associated with ADHD symptoms (beta [SD] = -0.077[0.033], P = 0.019). Dysregulation of melatonin secretion may be associated with the risk of ADHD.

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褪黑激素分泌的遗传风险与注意缺陷多动障碍之间的关系

睡眠问题在多动症患者中很常见，但其确切的内在机制尚不清楚。I 分析数据来自灵北基金会综合精神病学研究计划（N = 27,076 ）、台湾生物库（N = 2373）和滨松母子出生队列（N = 726）。基于连锁不平衡得分的遗传相关性分析表明，褪黑激素分泌与多动症诊断之间存在遗传相关性（rg[SD] = -0.134 [0.012]，P < 0.001）。多基因风险评分分析表明，与褪黑激素分泌有关的基因变异与多动症症状相关（β[SD] = -0.077[0.033], P = 0.019）。褪黑激素分泌失调可能与多动症风险有关。

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