Adipose-derived stem cell therapy for spinal cord injuries: Advances, challenges, and future directions

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING Regenerative Therapy Pub Date : 2024-06-01 DOI:10.1016/j.reth.2024.07.007

Yusuke Shimizu , Edward Hosea Ntege , Eisaku Takahara , Naoki Matsuura , Rikako Matsuura , Kota Kamizato , Yoshikazu Inoue , Yoshihiro Sowa , Hiroshi Sunami

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Abstract

Spinal cord injury (SCI) has limited treatment options for regaining function. Adipose-derived stem cells (ADSCs) show promise owing to their ability to differentiate into multiple cell types, promote nerve cell survival, and modulate inflammation. This review explores ADSC therapy for SCI, focusing on its potential for improving function, preclinical and early clinical trial progress, challenges, and future directions.

Preclinical studies have demonstrated ADSC transplantation's effectiveness in promoting functional recovery, reducing cavity formation, and enhancing nerve regrowth and myelin repair. To improve ADSC efficacy, strategies including genetic modification and combination with rehabilitation are being explored. Early clinical trials have shown safety and feasibility, with some suggesting motor and sensory function improvements.

Challenges remain for clinical translation, including optimizing cell survival and delivery, determining dosing, addressing tumor formation risks, and establishing standardized protocols. Future research should focus on overcoming these challenges and exploring the potential for combining ADSC therapy with other treatments, including rehabilitation and medication.

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脊髓损伤的脂肪源性干细胞疗法：进展、挑战和未来方向

脊髓损伤（SCI）恢复功能的治疗方案有限。脂肪源性干细胞（ADSCs）具有分化成多种细胞类型、促进神经细胞存活和调节炎症的能力，因此前景看好。本综述探讨了ADSC治疗SCI的方法，重点关注其改善功能的潜力、临床前和早期临床试验进展、挑战和未来方向。为了提高 ADSC 的疗效，目前正在探索包括基因修饰和与康复相结合的策略。早期临床试验显示了其安全性和可行性，其中一些试验表明运动和感觉功能有所改善。临床转化仍面临挑战，包括优化细胞存活和输送、确定剂量、解决肿瘤形成风险以及建立标准化方案。未来的研究应侧重于克服这些挑战，并探索将 ADSC疗法与其他疗法（包括康复和药物治疗）相结合的可能性。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.