Adoption of a Tetrahedral DNA Nanostructure as a Multifunctional Biomaterial for Drug Delivery

IF 4.9 Q1 CHEMISTRY, MEDICINAL ACS Pharmacology and Translational Science Pub Date : 2024-07-24 DOI:10.1021/acsptsci.4c0030810.1021/acsptsci.4c00308

Jiaqi Huang, Aishik Chakraborty, Lakshmi Suchitra Tadepalli and Arghya Paul*,

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Abstract

DNA nanostructures have been widely researched in recent years as emerging biomedical materials for drug delivery, biosensing, and cancer therapy, in addition to their hereditary function. Multiple precisely designed single-strand DNAs can be fabricated into complex, three-dimensional DNA nanostructures through a simple self-assembly process. Among all of the synthetic DNA nanostructures, tetrahedral DNA nanostructures (TDNs) stand out as the most promising biomedical nanomaterial. TDNs possess the merits of structural stability, cell membrane permeability, and natural biocompatibility due to their compact structures and DNA origin. In addition to their inherent advantages, TDNs were shown to have great potential in delivering therapeutic agents through multiple functional modifications. As a multifunctional material, TDNs have enabled innovative pharmaceutical applications, including antimicrobial therapy, anticancer treatment, immune modulation, and cartilage regeneration. Given the rapid development of TDNs in the biomedical field, it is critical to understand how to successfully produce and fine-tune the properties of TDNs for specific therapeutic needs and clinical translation. This article provides insights into the synthesis and functionalization of TDNs and summarizes the approaches for TDN-based therapeutics delivery as well as their broad applications in the field of pharmaceutics and nanomedicine, challenges, and future directions.

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采用四面体 DNA 纳米结构作为多功能生物材料进行药物输送

DNA 纳米结构作为一种新兴的生物医学材料，除了具有遗传功能外，还可用于药物输送、生物传感和癌症治疗，近年来已被广泛研究。通过简单的自组装过程，可以将多条精确设计的单链 DNA 制成复杂的三维 DNA 纳米结构。在所有合成的 DNA 纳米结构中，四面体 DNA 纳米结构（TDNs）是最有前途的生物医学纳米材料。四面体 DNA 纳米结构因其紧凑的结构和 DNA 起源而具有结构稳定性、细胞膜渗透性和天然生物相容性等优点。除了其固有的优点外，TDNs 还通过多种功能修饰，在递送治疗药物方面具有巨大潜力。作为一种多功能材料，TDNs 实现了创新药物应用，包括抗菌治疗、抗癌治疗、免疫调节和软骨再生。鉴于 TDNs 在生物医学领域的快速发展，了解如何成功生产和微调 TDNs 的特性以满足特定的治疗需求和临床转化至关重要。本文深入探讨了 TDNs 的合成和功能化，总结了基于 TDN 的治疗递送方法及其在制药学和纳米医学领域的广泛应用、挑战和未来发展方向。

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来源期刊

ACS Pharmacology and Translational Science Medicine-Pharmacology (medical)

CiteScore

10.00

自引率

3.30%

发文量

133

期刊介绍： ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action, and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest to the journal. Nonetheless, all innovative and impactful research that has an articulated translational relevance will be considered. ACS Pharmacology & Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition. Authors are encouraged to use the pre-submission inquiry mechanism to ensure relevance and appropriateness of research.