MASS cohort: Multicenter, longitudinal, and prospective study of the role of microbiome in severe pneumonia and host susceptibility

IF 23.7 Q1 MICROBIOLOGY iMeta Pub Date : 2024-06-25 DOI:10.1002/imt2.218

Xin Wei, Li Guo, Hongliu Cai, Silan Gu, Lingling Tang, Yuxin Leng, Minghui Cheng, Guojun He, Yijiao Han, Xindie Ren, Baoyue Lin, Longxian Lv, Huanzhang Shao, Mingqiang Wang, Hongyu Wang, Dan Dang, Shengfeng Wang, Nan Wang, Peng Shen, Qianqian Wang, Yinghe Xu, Yongpo Jiang, Ning Zhang, Xuwei He, Xuntao Deng, Muhua Dai, Lin Zhong, Yonghui Xiong, Yujie Pan, Kankai Tang, Fengqi Liu, Bin Yang, Lili Ren, Jianwei Wang, Chao Jiang, Lingtong Huang

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Abstract

The MASS cohort comprises 2000 ICU patients with severe pneumonia, covering community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia, sourced from 19 hospitals across 10 cities in three provinces. A wide array of samples including bronchoalveolar lavage fluid, sputum, feces, and whole blood are longitudinally collected throughout patients' ICU stays. The cohort study seeks to uncover the dynamics of lung and gut microbiomes and their associations with severe pneumonia and host susceptibility, integrating deep metagenomics and transcriptomics with detailed clinical data.

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MASS 队列：微生物组在重症肺炎和宿主易感性中的作用的多中心、纵向和前瞻性研究

MASS 队列由 2000 名重症肺炎 ICU 患者组成，包括社区获得性肺炎、医院获得性肺炎和呼吸机相关肺炎，患者来自三个省 10 个城市的 19 家医院。在患者入住重症监护病房的整个过程中纵向采集了支气管肺泡灌洗液、痰液、粪便和全血等多种样本。这项队列研究将深度元基因组学和转录组学与详细的临床数据相结合，旨在揭示肺部和肠道微生物组的动态变化及其与重症肺炎和宿主易感性的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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iMeta

CiteScore

10.80

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