Association Between Nickel Exposure and Metabolic Syndrome: Data from NHANES 2017-2018.

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Toxicology Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI:10.1007/s12012-024-09912-y
Xiao-Min Luo, Min Tang, Xiao-Hui Wei, Xiaofang Tang, Yong-De Peng
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Abstract

Previous studies have found a possible association between nickel and metabolic syndrome (MetS), but with conflicting results. No studies have determined whether nickel exposure increases the prevalence of MetS in the general U.S. population. Therefore, we used data from the National Health and Nutrition Examination Survey (NHANES) to assess the association between urinary nickel and MetS. Since urinary nickel levels were presented as a skewed distribution, they were normalized using a logarithmic transformation. Weighted multivariate logistic models, restricted cubic spline, threshold effect analysis, and subgroup analyses were used to examine the association between urinary nickel concentration and the risk of MetS and its components. Based on data from 1577 participants, individuals in the second, third, and fourth quartiles of urinary nickel had an adjusted OR for MetS of 1.42 (95% CI: 0.88, 2.28), 2.00 (95% CI: 1.22, 3.28), and 1.68 (95% CI: 1.05, 2.70), respectively, representing an inverted "L"-shaped nonlinear dose-response relationship with an inflection point at 0.2141 ng/L. Patients over the age of 40, males, less educated, and smokers are more susceptible to nickel exposure. In addition, there were significant associations between nickel and most components of the MetS, with the strongest to weakest correlations being high fasting glucose, reduced high-density lipoprotein, abdominal obesity, and elevated blood pressure; however, there was no significant correlation between nickel and hyperlipidemia. In conclusion, environmental nickel exposure increases the prevalence of MetS in U.S. adults, particularly in males over 40 years of age, those with less education, and smokers.

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镍暴露与代谢综合征之间的关系:来自 2017-2018 年 NHANES 的数据。
以往的研究发现,镍与代谢综合征(MetS)之间可能存在关联,但研究结果相互矛盾。目前还没有研究确定镍暴露是否会增加美国普通人群中 MetS 的患病率。因此,我们利用美国国家健康与营养调查(NHANES)的数据来评估尿镍与 MetS 之间的关系。由于尿镍水平呈偏态分布,因此采用对数变换对其进行归一化处理。采用加权多变量逻辑模型、限制性三次样条曲线、阈值效应分析和亚组分析来研究尿镍浓度与 MetS 风险及其组成部分之间的关系。根据 1577 名参与者的数据,尿镍浓度处于第二、第三和第四四分位数的人患 MetS 的调整后 OR 值分别为 1.42(95% CI:0.88,2.28)、2.00(95% CI:1.22,3.28)和 1.68(95% CI:1.05,2.70),呈现倒 "L "形的非线性剂量-反应关系,拐点为 0.2141 ng/L。年龄超过 40 岁、男性、教育程度较低和吸烟的患者更容易受到镍暴露的影响。此外,镍与 MetS 的大多数成分之间存在明显的相关性,从强到弱的相关性依次为空腹血糖高、高密度脂蛋白降低、腹部肥胖和血压升高;但是,镍与高脂血症之间没有明显的相关性。总之,环境中的镍暴露会增加美国成年人的 MetS 患病率,尤其是 40 岁以上的男性、教育程度较低的人群和吸烟者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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