Karlo J Lizarraga, Bhairavei Gnanamanogaran, Tameem M Al-Ozzi, Melanie Cohn, George Tomlinson, Alexandre Boutet, Gavin J B Elias, Jürgen Germann, Derrick Soh, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Connie Marras, William D Hutchison, Andres M Lozano, Anthony E Lang, Alfonso Fasano
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引用次数: 0
Abstract
Background: A randomized trial suggested that reducing left-sided subthalamic stimulation amplitude could improve axial dysfunction.
Objectives: To explore open-label tolerability and associations between trial outcomes and asymmetry data.
Methods: We collected adverse events in trial participants treated with open-label lateralized settings for ≥3 months. We explored associations between trial outcomes, location of stimulation and motor asymmetry.
Results: 14/17 participants tolerated unilateral amplitude reduction (left-sided = 10, right-sided = 4). Two hundred eighty-four left-sided and 1113 right-sided stimulated voxels were associated with faster gait velocity, 81 left-sided and 22 right-sided stimulated voxels were associated with slower gait velocity. Amplitude reduction contralateral to shorter step length was associated with 2.4-point reduction in axial MDS-UPDRS. Reduction contralateral to longer step length was associated with 10-point increase in MDS-UPDRS.
Conclusions: Left-sided amplitude reduction is potentially more tolerable than right-sided amplitude reduction. Right-sided more than left-sided stimulation could be associated with faster gait velocity. Shortened step length might reflect contralateral overstimulation.
期刊介绍：
Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)
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