Developing a recovery process for bioactives from discarded by-products of winemaking industry based on multivariate optimization method: Deep eutectic solvents as eco-friendly extraction media.

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS Phytochemical Analysis Pub Date : 2024-12-01 Epub Date: 2024-08-13 DOI:10.1002/pca.3434

Sena Kavas, Alara Erbaşar, Ebru Kurtulbaş, Serena Fiorito, Selin Şahin

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Abstract

Introduction: The recovery process for bioactives from discarded by-products of the winemaking industry is of great value considering both environmental and economic aspects.

Objective: The goal of this study is to investigate the extraction of phenolic antioxidants from grape (Vitis vinifera) seeds by means of carboxylic acid-based deep eutectic solvents (DESs) in order to propose an environmentally friendly method based on a multivariate optimization approach.

Material and methods: Carboxylic acid-based DESs were designed with several molar ratios (1/1, 1/2, and 2/1). Two polyols (glycerol and ethylene glycol) were used as hydrogen bond donors, while formic acid, acetic acid, and propionic acid were selected as hydrogen bond acceptors. The process parameters (water content, extraction time, and solid mass) were analyzed to optimize the process through Box-Behnken design with response surface method, after determination of the best combination for the highest total phenolic content (TPC) and the antioxidant activity yields.

Results: The maximum TPC yield (153.17 ± 0.003 mg-GAE/g-GS) and antioxidant activity yield (82.26 ± 0.004 mg-GAE/g-GS) were achieved by 50% water addition into the DES (ethylene glycol/acetic acid, 1/1), 85 sec extraction time, and 0.1 g grape seed.

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基于多元优化方法，开发从酿酒业废弃副产品中回收生物活性物质的工艺：作为生态友好型萃取介质的深共晶溶剂。

导言：从酿酒业废弃的副产品中回收生物活性物质，从环境和经济两方面考虑都具有重要价值：本研究的目的是通过羧酸基深共晶溶剂（DES）研究从葡萄（葡萄属）种子中提取酚类抗氧化剂的方法，从而提出一种基于多元优化方法的环境友好型方法：设计了几种摩尔比（1/1、1/2 和 2/1）的羧酸基 DES。采用两种多元醇（甘油和乙二醇）作为氢键供体，甲酸、乙酸和丙酸作为氢键受体。在确定总酚含量（TPC）和抗氧化活性产率最高的最佳组合后，采用响应面法对工艺参数（含水量、萃取时间和固体质量）进行了分析，以优化工艺：结果：在 DES（乙二醇/乙酸，1/1）中加水 50%、萃取时间 85 秒、葡萄籽 0.1 克的条件下，TPC 产量（153.17 ± 0.003 mg-GAE/g-GS）和抗氧化活性产量（82.26 ± 0.004 mg-GAE/g-GS）最高。

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来源期刊

Phytochemical Analysis 生物-分析化学

CiteScore

6.00

自引率

6.10%

发文量

审稿时长

1.7 months

期刊介绍： Phytochemical Analysis is devoted to the publication of original articles concerning the development, improvement, validation and/or extension of application of analytical methodology in the plant sciences. The spectrum of coverage is broad, encompassing methods and techniques relevant to the detection (including bio-screening), extraction, separation, purification, identification and quantification of compounds in plant biochemistry, plant cellular and molecular biology, plant biotechnology, the food sciences, agriculture and horticulture. The Journal publishes papers describing significant novelty in the analysis of whole plants (including algae), plant cells, tissues and organs, plant-derived extracts and plant products (including those which have been partially or completely refined for use in the food, agrochemical, pharmaceutical and related industries). All forms of physical, chemical, biochemical, spectroscopic, radiometric, electrometric, chromatographic, metabolomic and chemometric investigations of plant products (monomeric species as well as polymeric molecules such as nucleic acids, proteins, lipids and carbohydrates) are included within the remit of the Journal. Papers dealing with novel methods relating to areas such as data handling/ data mining in plant sciences will also be welcomed.