Biomarkers and Endophenotypes of Post-traumatic Headaches.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY Current Pain and Headache Reports Pub Date : 2024-08-13 DOI:10.1007/s11916-024-01255-1

Joshua L Kamins, Ramin Karimi, Ann Hoffman, Mayumi L Prins, Christopher C Giza

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Abstract

Purpose of review: To review existing literature on biomarkers for post-traumatic headache (PTH).

Recent findings: Preclinical models and clinical findings have started to elucidate the biology that underlies PTH. Traumatic brain injury results in ionic flux, glutamatergic surge, and activation of the trigeminal cervical complex resulting in the release of pain neuropeptides. These neuropeptides, including calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP), play a key role in the pathophysiology of migraine and other primary headache disorders. Only two studies were identified that evaluated CGRP levels in PTH. Neither study found a consistent relationship between CGRP levels and PTH. One study did discover that nerve growth factor (NGF) was elevated in subjects with PTH. There is no conclusive evidence for reliable blood-based biomarkers for PTH. Limitations in assays, collection technique, and time since injury must be taken into account. There are multiple ideal candidates that have yet to be explored.

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创伤后头痛的生物标志物和内表型。

综述目的：回顾有关创伤后头痛（PTH）生物标志物的现有文献：临床前模型和临床发现已开始阐明 PTH 的生物学基础。创伤性脑损伤会导致离子通量、谷氨酸能激增以及三叉神经颈复合体的激活，从而导致疼痛神经肽的释放。这些神经肽包括降钙素基因相关肽（CGRP）和垂体腺苷酸环化酶激活多肽（PACAP），在偏头痛和其他原发性头痛疾病的病理生理学中起着关键作用。目前仅发现两项研究评估了 PTH 中的 CGRP 水平。这两项研究均未发现 CGRP 水平与 PTH 之间存在一致的关系。有一项研究发现，PTH 患者的神经生长因子（NGF）升高。目前还没有确凿证据表明血液中存在可靠的 PTH 生物标志物。必须考虑到检测方法、采集技术和受伤后时间等方面的局限性。有多种理想的候选指标尚待探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.