Associations between Earlobe Creases and Magnetic Resonance Imaging Small Vessel Disease Markers in a Chinese Cohort of Patients with Ischemic Stroke.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY Cerebrovascular Diseases Pub Date : 2024-08-13 DOI:10.1159/000540816

Weiyin Cao, Xiuman Xu, Lixuan Wang, Chenchen Liu, Qin Fu, Shiya Zhang, Jiaping Xu, Zhichao Huang, Wu Cai, Shoujiang You, Yongjun Cao

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Abstract

Introduction: The association between earlobe crease (ELC) and cerebral small vessel disease, including white matter hyperintensities (WMHs) and brain atrophy, is unclear, especially in the setting of acute ischemic stroke (AIS). Here, we aimed to investigate the association between ELC and WMHs as well as brain atrophy among AIS patients.

Methods: A total of 730 AIS patients from China were enrolled. Patients were divided into groups without and with ELC, unilateral and bilateral ELC according to pictures of bilateral ears. Logistic regression models were employed to assess the impact of ELC, bilateral ELC on WMHs, periventricular hyperintensities (PVHs), deep white matter hyperintensities (DWMHs), and brain atrophy, as measured by the Fazekas scale and global cortical atrophy scale, in brain magnetic resonance imaging.

Results: There were 520 (71.2%) AIS patients with WMHs, 445 (61.0%) with PVH, 462 (63.3%) with DWMH, and 586 (80.3%) with brain atrophy. Compared to those without ELC, patients with ELC were significantly associated with an increased risk of PVH (odds ratio [OR] 1.79; 95% confidence interval [CI], 1.15-2.77) and brain atrophy (OR: 6.18; 95% CI: 3.60-10.63) but not WMHs and DWMH. The presence of bilateral ELC significantly increased the odds of WMHs (OR: 1.60; 95% CI: 1.00-2.56), PVH (OR: 1.87; 95% CI: 1.18-2.96), and brain atrophy (OR: 8.50; 95% CI: 4.62-15.66) when compared to individuals without ELC. Furthermore, we discovered that the association between bilateral ELC and WMHs, PVH, and DWMH was significant only among individuals aged ≤68 (median age) years (all p trend ≤0.041). However, this association was not observed in patients older than 68 years.

Conclusions: In Chinese AIS patients, the presence of the visible aging sign, ELC, especially bilateral ELC, showed independent associations with both WMHs and brain atrophy, particularly among those younger than 68 years old.

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中国缺血性脑卒中患者队列中耳垂褶皱与磁共振成像 SVD 标志物之间的关系。

背景：耳垂皱襞（ELC）与脑小血管疾病（CSVD）（包括白质高密度（WMH）和脑萎缩）之间的关系尚不清楚，尤其是在急性缺血性卒中（AIS）的情况下。在此，我们旨在研究 ELC 与 WMHs 以及 AIS 患者脑萎缩之间的关系：方法：共招募了 730 名中国 AIS 患者。根据双耳照片将患者分为无 ELC 组和有 ELC 组、单侧 ELC 组和双侧 ELC 组。采用逻辑回归模型评估ELC、双侧ELC对脑磁共振成像（MRI）中WMHs、脑室周围高密度（PVH）、深部白质高密度（DWMH）和脑萎缩（以Fazekas量表和全球皮质萎缩量表测量）的影响：520例（71.2%）AIS患者伴有WMH，445例（61.0%）伴有PVH，462例（63.3%）伴有DWMH，586例（80.3%）伴有脑萎缩。与没有 ELC 的患者相比，有 ELC 的患者发生 PVH（几率比 [OR] 1.79；95% 置信区间 [CI]，1.15-2.77）和脑萎缩（OR 6.18；95% CI，3.60-10.63）的风险显著增加，但发生 WMH 和 DWMH 的风险没有增加。与没有 ELC 的个体相比，存在双侧 ELC 会明显增加出现 WMHs（OR 1.60；95% CI，1.00-2.56）、PVH（OR 1.87；95% CI，1.18-2.96）和脑萎缩（OR 8.50；95% CI，4.62-15.66）的几率。此外，我们还发现，双侧 ELC 与 WMHs、PVH 和 DWMH 之间的关联仅在年龄≤68（中位年龄）的个体中具有显著性（所有 P 趋势均≤0.041）。结论：结论：在中国的AIS患者中，可见老化征象ELC的存在，尤其是双侧ELC的存在，与白质高密度和脑萎缩都有独立的关联，特别是在68岁以下的患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.