A Meta-analysis of Different Acupuncture Modalities Combined With Antidepressants to Reduce Major Depressive Disorder.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY Clinical Neuropharmacology Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI:10.1097/WNF.0000000000000606

Wanqing Shu, Yongzhen Pan

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Abstract

Objectives: Acupuncture is an effective therapy for depression. Nevertheless, the results of clinical studies on major depressive disorder (MDD) remain controversial.

Methods: By November 2023, English-language published randomized clinical trials involving acupuncture for treating MDD were searched. The analysis comprised 9 studies with 809 subjects who met the eligibility criteria. The quality of the included studies was evaluated using the Quality in Prognostic Studies (QUIPS) tool.

Results: Acupuncture moderately alleviated the severity of MDD, independent of the method used (standardized mean difference [SMD] = -0.55; confidence interval [CI] 95%: -1.19, 0.09; P = 0.08). The severity of MDD was moderated by MA, regardless of antidepressant use (SMD = -0.49; CI95%: -1.13, 0.14, P = 0.09). Subgroup analysis revealed a nonsignificant reduction in MDD severity when using manual acupuncture alone (SMD -0.52; CI95%: -1.47, 0.44, P = 0.18). MDD severity was reduced by the use of manual acupuncture and antidepressants (SMD = -0.47; CI95%: -0.88, -0.06). Laser acupuncture and electroacupuncture (with or without antidepressants) did not significantly affect the severity of MDD.

Conclusions: Manual acupuncture with or without antidepressants may alleviate the severity of MDD, but its clinical benefit for treating MDD is inconclusive.

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不同针灸模式与抗抑郁药联合治疗重度抑郁症的 Meta 分析》（Meta-analysis of Different Acupuncture Modalities Combined With Antidepressants to Reduce Major Depressive Disorder）。

目的：针灸是治疗抑郁症的有效方法。然而，针对重度抑郁症（MDD）的临床研究结果仍存在争议：方法：检索了截至 2023 年 11 月发表的涉及针灸治疗 MDD 的英文随机临床试验。分析包括 9 项研究，809 名受试者符合资格标准。采用预后研究质量（QUIPS）工具对纳入研究的质量进行了评估：结果：针灸可适度缓解 MDD 的严重程度，与使用的方法无关（标准化平均差 [SMD] = -0.55；置信区间 [CI] 95%：-1.19, 0.09; P = 0.08).无论是否使用抗抑郁药，MDD的严重程度都会受到MA的调节（SMD = -0.49；CI95%：-1.13，0.14；P = 0.09）。亚组分析显示，单独使用人工针灸时，MDD 严重程度的降低并不显著（SMD = -0.52；CI95%：-1.47，0.44，P = 0.18）。使用手法针灸和抗抑郁药物可减轻 MDD 的严重程度（SMD = -0.47；CI95%：-0.88，-0.06）。激光针灸和电针（无论是否使用抗抑郁药物）对 MDD 的严重程度没有显著影响：结论：无论是否服用抗抑郁药物，徒手针灸均可减轻多发性硬化症的严重程度，但其治疗多发性硬化症的临床疗效尚无定论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.