Relationship between CCL2 gene 2518A/G (rs1024611) polymorphism and age-related macular degeneration susceptibility: meta-analysis and trial sequential analysis.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY International Ophthalmology Pub Date : 2024-08-14 DOI:10.1007/s10792-024-03266-8

Haokun Tian, Weikai Xu, Lequan Wen, Tiangang Song, Ye Tian, Lirui Tang, Nan Guo, Qianxi Chen, Haoran Wang, Kaiyuan Zhang, Xinyuan Zhang, Yu Peng

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Abstract

Purpose: This study aimed to investigate the association between the CC-cytokine ligand-2 (CCL2) 2518A/G (rs1024611) single nucleotide polymorphism (SNP) and susceptibility to age-related macular degeneration (AMD).

Methods: PubMed, Embase, Web of Science, and other databases were searched for articles published before August 24, 2023. After searching, data extraction, and quality assessment, meta-analysis and trial sequential analysis were conducted using RevMan 5.4, Stata 17.0, and TSA 0.9.5.10 Beta software. Combined OR, P values, and 95% confidence intervals (CIs) were calculated. Sensitivity analysis, subgroup analysis and publication bias assessment were also performed.

Results: Six articles, comprising 1186 cases and 1124 controls, were included. No significant statistical difference was found in six main outcomes. However, due to observed heterogeneity and high sensitivity, subgroup analysis was performed, revealing statistically significant differences across different regions. No significant publication bias was observed. Trial sequential analysis suggested the need for additional follow-up case-control studies to further validate the findings.

Conclusion: The CCL2 gene 2518A/G (rs1024611) polymorphism is associated with AMD susceptibility. Among Caucasian populations in West Asia and Europe, the G allele is protective against AMD, whereas in East and South Asia, it poses a risk factor.

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CCL2基因2518A/G（rs1024611）多态性与老年性黄斑变性易感性之间的关系：荟萃分析和试验序列分析。

目的：本研究旨在探讨CC-细胞因子配体-2（CCL2）2518A/G（rs1024611）单核苷酸多态性（SNP）与老年性黄斑变性（AMD）易感性之间的关联：在 PubMed、Embase、Web of Science 和其他数据库中检索 2023 年 8 月 24 日之前发表的文章。在搜索、数据提取和质量评估之后，使用RevMan 5.4、Stata 17.0和TSA 0.9.5.10 Beta软件进行了荟萃分析和试验序列分析。计算了合并 OR、P 值和 95% 置信区间 (CI)。此外，还进行了敏感性分析、亚组分析和发表偏倚评估：结果：共纳入六篇文章，包括 1186 例病例和 1124 例对照。在六项主要结果中未发现明显的统计学差异。然而，由于观察到的异质性和高敏感性，我们进行了亚组分析，发现不同地区之间存在显著的统计学差异。未发现明显的发表偏倚。试验序列分析表明，需要进行更多的后续病例对照研究，以进一步验证研究结果：结论：CCL2基因2518A/G（rs1024611）多态性与AMD易感性有关。结论：CCL2基因2518A/G（rs1024611）多态性与AMD易感性有关，在西亚和欧洲的白种人中，G等位基因对AMD具有保护作用，而在东亚和南亚，G等位基因则是一个危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.