{"title":"Peripapillary and Macular Vessel Density in Unilateral Early Pseudoexfoliation Glaucoma.","authors":"Nilgun Solmaz, Turker Oba","doi":"10.1097/IJG.0000000000002483","DOIUrl":null,"url":null,"abstract":"<p><strong>Precis: </strong>In early pseudoexfoliation glaucoma, radial peripapillary capillary vessel density (RPC-VD) was reduced nasally, while the retinal nerve fiber layer (RNFL) thinned from the nasal to temporal sectors. Nonglaucomatous fellow eyes demonstrated no RPC-VD or RNFL loss in comparison to the controls.</p><p><strong>Purpose: </strong>To evaluate peripapillary and macular vessel density (VD) in unilateral early pseudoexfoliation glaucoma (PXG) and unaffected fellow eyes compared to healthy controls.</p><p><strong>Methods: </strong>This cross-sectional study included 28 eyes with PXG and 28 nonglaucomatous, pseudoexfoliation-free fellow eyes of 28 patients and 28 eyes of 28 healthy participants. All subjects underwent optical coherence tomography angiography (OCTA) imaging. Radial peripapillary capillary VD (RPC-VD), macular VD, retinal nerve fiber layer (RNFL) thickness, and ganglion cell complex (GCC) thickness were compared among the groups.</p><p><strong>Results: </strong>The average RPC-VD and RNFL thickness were significantly reduced in PXG eyes compared to both fellow eyes and the control group (P<0.001-0.002). In fellow eyes, neither RNFL thickness nor RPC-VD parameters differed from controls. In sector-based analysis, RPC-VD loss in the PXG eyes was significant in the nasal-superior, nasal-inferior, superonasal, and inferonasal sectors (P=0.005-0.031), while RNFL thinning extended from the nasal sectors toward the superotemporal and temporal-superior sectors (P<0.001-0.014). RPC-VD was strongly correlated with average and all sector RNFL thicknesses (r=0.402-0.759, P<0.001-0.034). While perifoveal GCC differed from both fellow and control eyes (P<0.001), there was no significant difference in macular VD parameters among the groups. RPC-VD and RNFL had comparable area under receiver operating curve (AUROC) values in the average and nasal sectors, while RPC-VD had no ability to distinguish PXG from controls in the superotemporal and inferotemporal sectors.</p><p><strong>Conclusion: </strong>In the early stages of PXG, RNFL parameters mostly appear to have better diagnostic ability than RPC-VD parameters. Fellow eyes in the preclinical stage may not exhibit any RPC-VD and RNFL loss detectable by current OCTA technology.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Glaucoma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/IJG.0000000000002483","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Precis: In early pseudoexfoliation glaucoma, radial peripapillary capillary vessel density (RPC-VD) was reduced nasally, while the retinal nerve fiber layer (RNFL) thinned from the nasal to temporal sectors. Nonglaucomatous fellow eyes demonstrated no RPC-VD or RNFL loss in comparison to the controls.
Purpose: To evaluate peripapillary and macular vessel density (VD) in unilateral early pseudoexfoliation glaucoma (PXG) and unaffected fellow eyes compared to healthy controls.
Methods: This cross-sectional study included 28 eyes with PXG and 28 nonglaucomatous, pseudoexfoliation-free fellow eyes of 28 patients and 28 eyes of 28 healthy participants. All subjects underwent optical coherence tomography angiography (OCTA) imaging. Radial peripapillary capillary VD (RPC-VD), macular VD, retinal nerve fiber layer (RNFL) thickness, and ganglion cell complex (GCC) thickness were compared among the groups.
Results: The average RPC-VD and RNFL thickness were significantly reduced in PXG eyes compared to both fellow eyes and the control group (P<0.001-0.002). In fellow eyes, neither RNFL thickness nor RPC-VD parameters differed from controls. In sector-based analysis, RPC-VD loss in the PXG eyes was significant in the nasal-superior, nasal-inferior, superonasal, and inferonasal sectors (P=0.005-0.031), while RNFL thinning extended from the nasal sectors toward the superotemporal and temporal-superior sectors (P<0.001-0.014). RPC-VD was strongly correlated with average and all sector RNFL thicknesses (r=0.402-0.759, P<0.001-0.034). While perifoveal GCC differed from both fellow and control eyes (P<0.001), there was no significant difference in macular VD parameters among the groups. RPC-VD and RNFL had comparable area under receiver operating curve (AUROC) values in the average and nasal sectors, while RPC-VD had no ability to distinguish PXG from controls in the superotemporal and inferotemporal sectors.
Conclusion: In the early stages of PXG, RNFL parameters mostly appear to have better diagnostic ability than RPC-VD parameters. Fellow eyes in the preclinical stage may not exhibit any RPC-VD and RNFL loss detectable by current OCTA technology.
期刊介绍:
The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.