The causal relationship between androgenetic alopecia and serum uric acid: A bidirectional Mendelian randomization analysis.

IF 2 4区医学 Q3 DERMATOLOGY Skin Research and Technology Pub Date : 2024-08-01 DOI:10.1111/srt.13912

Yan Yu, Shu Wang, Zijun Wu, Jinru Lin, Huiping Wang

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Abstract

Background: Despite numerous studies investigating the association between androgenetic alopecia (AGA) and serum uric acid (SUA), the causal relationship between AGA and SUA remains unknown.

Methods: We utilized bidirectional Mendelian randomization (MR) to explore the causality between AGA and SUA. Our study chose single nucleotide polymorphisms associated with genome-wide significance (p < 5×10^-8) for the exposure and showing low linkage disequilibrium (R² < 0.001) as IVs. Various MR methods were employed to evaluate causality, including inverse-variance weighted (IVW), Weighted Median, MR-Egger, Weighted Mode and Simple Mode. Sensitivity analyses were performed to test the robustness of the results.

Results: Using the IVW method, we did not find a significant causal relationship between AGA and SUA (OR = 1.00, 95% CI 0.99-1.01; p = 0.451). Similarly, the IVW method did not reveal evidence of causality between SUA and AGA (OR = 0.97, 95% CI = 0.91-1.03; p = 0.301). The results from other methods were consistent with those of the IVW approach.

Conclusion: The study did not identify a causal relationship between AGA and SUA. Future research should involve larger cohorts and advanced methods to validate the findings and explore the complex interactions between AGA and SUA levels in different populations.

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雄激素性脱发与血清尿酸之间的因果关系：双向孟德尔随机分析

背景：尽管有许多研究调查了雄激素性脱发（AGA）与血清尿酸（SUA）之间的关系，但AGA与SUA之间的因果关系仍然未知：方法：我们利用双向孟德尔随机化（MR）来探讨AGA与SUA之间的因果关系。我们的研究选择了与暴露相关的单核苷酸多态性，这些多态性具有全基因组意义（p -8），并显示出较低的连锁不平衡（R2 结果）：使用 IVW 方法，我们没有发现 AGA 与 SUA 之间存在显著的因果关系（OR = 1.00，95% CI 0.99-1.01；p = 0.451）。同样，IVW 方法也没有发现 SUA 与 AGA 之间存在因果关系的证据（OR = 0.97，95% CI = 0.91-1.03；p = 0.301）。其他方法的结果与 IVW 方法的结果一致：本研究并未发现 AGA 与 SUA 之间存在因果关系。未来的研究应采用更大规模的队列和更先进的方法来验证研究结果，并探索不同人群中 AGA 和 SUA 水平之间复杂的相互作用。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.