Deciphering the impairment of perimenopausal insomnia on visual search from a neurocognitive processing perspective.

IF 5.6 2区医学 Q1 Medicine Sleep Pub Date : 2024-11-08 DOI:10.1093/sleep/zsae188

Liyong Yu, Yucai Luo, Wenting Lin, Zeyang Dou, Daijie Hu, Wei Wei, Yuqi He, Keli Zhu, Xiaojuan Hong, Qi Zhang, Siyi Yu

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Abstract

Study objectives: Perimenopausal insomnia (PMI) is associated with observable performance impairments in visual search tasks. This study examines how various cognitive processing stages contribute to search performance delays in PMI compared to healthy controls (HCs).

Methods: We recruited 76 participants diagnosed with PMI and 63 HCs. Event-related potentials (ERPs) were recorded as participants engaged in a visual search task, reporting the orientation of a color popout target within an array of ellipses. We analyzed group differences in behavioral performance and ERP components across cognitive processing stages.

Results: Compared to HCs, PMI patients exhibited behavioral response delays, although accuracy was not different between groups. Electrophysiological analyses revealed group differences across several ERP components. Firstly, the N1 component's amplitude increased bilaterally, suggesting enhanced visual sensory processing. Secondly, a slower and smaller N2pc indicated reduced attentional orienting. Thirdly, a decreased sustained posterior-contralateral negativity amplitude pointed to deficits in target discrimination. Fourthly, an increased amplitude of the stimulus-locked lateralized readiness potential (LRP), with unchanged latency, suggested heightened neural inputs for maintaining motor initiation speed. Fifthly, prolonged response-locked LRP latency indicated slower motor execution. Finally, these changes in ERP components, along with significant correlations between LRP components and insomnia symptoms, suggest potential neural biomarkers for PMI.

Conclusions: Our findings provide high-temporal-resolution insights into the neurocognitive disruptions associated with PMI, highlighting how sleep disturbances affect cognitive processing in visual tasks. These insights enhance our understanding of PMI and contribute to discussions on neural mechanisms driving behavioral performance in various conditions.

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从神经认知加工角度解读围绝经期失眠对视觉搜索的影响

研究目的围绝经期失眠症（PMI）与视觉搜索任务中可观察到的表现障碍有关。与健康对照组（HCs）相比，本研究探讨了各种认知加工阶段如何导致 PMI 患者搜索表现延迟：我们招募了 76 名确诊为 PMI 的参与者和 63 名 HCs。当参与者参与视觉搜索任务时，我们记录了事件相关电位（ERP），该任务是报告椭圆阵列中彩色弹出目标的方向。我们分析了不同认知加工阶段的行为表现和ERP成分的组间差异：结果：与普通人相比， PMI 患者表现出行为反应延迟，但各组之间的准确性并无差异。电生理分析表明，几种ERP成分存在组间差异。首先，N1成分的双侧振幅增大，表明视觉感觉处理增强。其次，N2pc 较慢且较小，表明注意定向能力减弱。第三，SPCN振幅减小，表明目标辨别能力下降。第四，在潜伏期不变的情况下，刺激锁定 LRP 的振幅增大，表明维持运动启动速度的神经输入增加。第五，反应锁定 LRP 潜伏期延长表明运动执行速度减慢。最后，ERP成分的这些变化，以及LRP成分与失眠症状之间的显著相关性，提示了潜在的PMI神经生物标志物：我们的研究结果提供了与 PMI 相关的神经认知干扰的高时空分辨率洞察，突出了睡眠障碍如何影响视觉任务中的认知处理。这些见解加深了我们对 PMI 的理解，并有助于讨论驱动各种情况下行为表现的神经机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.