Dana Branzei , Szabolcs Bene , Laxman Gangwani , Barnabas Szakal
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引用次数: 0
Abstract
At the core of cellular life lies a carefully orchestrated interplay of DNA replication, recombination, chromatin assembly, sister-chromatid cohesion and transcription. These fundamental processes, while seemingly discrete, are inextricably linked during genome replication. A set of replisome factors integrate various DNA transactions and contribute to the transient formation of sister chromatid junctions involving either the cohesin complex or DNA four-way junctions. The latter structures serve DNA damage bypass and may have additional roles in replication fork stabilization or in marking regions of replication fork blockage. Here, we will discuss these concepts based on the ability of one replisome component, Ctf4, to act as a hub and functionally link these processes during DNA replication to ensure genome maintenance.
细胞生命的核心是 DNA 复制、重组、染色质组装、姐妹染色单体内聚和转录等精心安排的相互作用。这些基本过程看似互不关联，但在基因组复制过程中却有着千丝万缕的联系。一组复制体因子整合了各种 DNA 事务，并有助于姊妹染色单体连接的瞬时形成，这些连接涉及凝聚素复合体或 DNA 四向连接。后一种结构可用于 DNA 损伤旁路，并可能在复制叉稳定或标记复制叉阻断区域方面发挥额外作用。在这里，我们将根据一个复制体成分 Ctf4 在 DNA 复制过程中充当枢纽并在功能上连接这些过程以确保基因组维护的能力来讨论这些概念。
期刊介绍：
DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease.
DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.
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