Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal injury by regulating the EGFR/Src/FAK pathway in an intracerebral hemorrhage rat model
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引用次数: 0
Abstract
The destruction of the blood-brain barrier and damage to the gastrointestinal mucosa after intracerebral hemorrhage (ICH) are important reasons for its high disability and mortality rates. However, the exact etiology is not yet clear. In addition, there are currently no effective treatments for improving cerebral edema and gastric mucosal damage after ICH. Trefoil factor 1 (TFF1) is a secretory protein that plays a crucial role in maintaining the integrity and barrier function of the gastric mucosa, and it has been reported to have a protective effect on brain damage induced by various causes. This study utilized a rat model of ICH induced by type IV collagenase was utilized, and intervened with recombinant TFF1 protein from an external institute to investigate the protective mechanisms of TFF1 against brain edema and gastric mucosal damage after ICH. The results demonstrated that TFF1 alleviated the neurological function and gastric mucosal damage in the rat model of ICH induced by type IV collagenase. TFF1 may ensure the integrity of the blood-brain and gastric mucosal barriers by regulating the EGFR (epidermal growth factor receptor)/Src (non-receptor tyrosine kinase)/FAK (focal adhesion kinase) pathway. Clearly, the disruption of the blood-brain barrier and the destruction of the gastric mucosal barrier are key pathological features of ICH, and TFF1 can improve the progression of blood-brain barrier and gastric mucosal barrier disruption in ICH by regulating the EGFR/Src/FAK pathway. Therefore, TFF1 may be a potential target for the treatment of ICH.
脑内出血（ICH）后血脑屏障的破坏和胃肠道粘膜的损伤是其致残率和死亡率高的重要原因。然而，确切的病因尚不清楚。此外，目前还没有有效的治疗方法来改善 ICH 后的脑水肿和胃黏膜损伤。三叶草因子 1（TFF1）是一种分泌蛋白，在维持胃黏膜的完整性和屏障功能方面起着至关重要的作用，有报道称它对各种原因引起的脑损伤有保护作用。本研究利用Ⅳ型胶原酶诱导的大鼠ICH模型，并用外院的重组TFF1蛋白进行干预，研究TFF1对ICH后脑水肿和胃黏膜损伤的保护机制。结果表明，TFF1 可减轻Ⅳ型胶原酶诱导的 ICH 大鼠模型的神经功能和胃黏膜损伤。TFF1可通过调节表皮生长因子受体（EGFR）/非受体酪氨酸激酶（Src）/焦点粘附激酶（FAK）通路，确保血脑屏障和胃粘膜屏障的完整性。显然，血脑屏障的破坏和胃黏膜屏障的破坏是 ICH 的主要病理特征，而 TFF1 可通过调节表皮生长因子受体/Src/FAK 通路改善 ICH 中血脑屏障和胃黏膜屏障破坏的进展。因此，TFF1可能是治疗ICH的潜在靶点。
期刊介绍：
The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems.
The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.
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